Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol

Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time c...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2008-12, Vol.55 (12), p.2691-2700
Main Authors: Plawecki, M.H., Jae-Joon Han, Doerschuk, P.C., Ramchandani, V.A., O'Connor, S.J.
Format: Article
Language:English
Subjects:
Absorption
Alcohol
Biomedical computing
Biomedical engineering
Brain modeling
Differential equations
Dose-Response Relationship, Drug
Ethanol
Ethanol - administration & dosage
Ethanol - analysis
Ethanol - pharmacokinetics
Humans
Infusions, Intravenous
Kinetic theory
Liver - metabolism
Mathematical model
Metabolic Clearance Rate
Models, Biological
Nonlinear Dynamics
Nonlinear equations
pharmacokinetics
physiologically based pharmacokinetic (PBPK) models
physiology
Tissue Distribution - physiology
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Description
Summary:Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for several pharmacokinetic and pharmacodynamic investigations. Mathematical foundations of these models are examined, including the derivation of an explicit set of governing equations in the form of a system of nonlinear ordinary differential equations. These equations can then be used to formulate and refine parameter identification and control strategies. Finally, a framework in which models related to this model can be constructed and analyzed is described.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2008.919132