Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations

Background: Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein. Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superan...

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Bibliographic Details
Published in:Multiple sclerosis 2011-04, Vol.17 (4), p.397-403
Main Authors: Mulvey, Michael R, Doupe, Malcolm, Prout, Michael, Leong, Christine, Hizon, Romeo, Grossberndt, Amy, Klowak, Meghann, Gupta, Aneri, Melanson, Maria, Gomori, Andrew, Esfahani, Farid, Klassen, Loressa, Frost, Emma E, Namaka, Michael
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Enterotoxins - immunology
Female
Humans
Logistic Models
Male
Medical sciences
Middle Aged
Multiple Sclerosis - immunology
Multiple Sclerosis - microbiology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nasal Cavity - immunology
Neurology
Risk Factors
Staphylococcal Infections - immunology
Staphylococcus aureus
Staphylococcus aureus - immunology
Superantigens - immunology
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Summary:Background: Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein. Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superantigens. Methods: Nasal swabs were collected from non-MS subjects and patients with MS who had not experienced a relapse in the past six months (MS stable group) and who had suffered a relapse within 30 days of study recruitment (MS exacerbation group). S. aureus was isolated from the anterior nares of participants following standard procedures and staphylococcal superantigen genes (sea, seb, and tsst-1) were detected using standard laboratory PCR techniques. Results: The study enrolled 204 patients, 80 in the non-MS and MS stable groups and 44 patients in the MS exacerbation group. Overall, 27.0% of patients were colonized with S. aureus with no significant differences identified between study groups. Amongst individuals colonized with S. aureus, the prevalence of sea was significantly greater in the MS exacerbation versus non-MS study group (p 
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458510391343