The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE)

Abstract Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (A...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2011-06, Vol.45 (3), p.189-195
Main Authors: Wasilewska, Jolanta, Sienkiewicz-Szłapka, Edyta, Kuźbida, Ewa, Jarmołowska, Beata, Kaczmarski, Maciej, Kostyra, Elżbieta
Format: Article
Language:English
Subjects:
Advanced Basic Science
ALTE
Animals
Apnea - blood
Biological and medical sciences
Breast feeding
Cattle
Dipeptidyl Peptidase 4 - blood
Dipeptidyl peptidase IV
Endocrinology & Metabolism
Endorphins - blood
Formula feeding
Fundamental and applied biological sciences. Psychology
Humans
Infant
Opioid peptides
Opioid Peptides - blood
Peptide Fragments - blood
SIDS
Sudden Infant Death
Vertebrates: endocrinology
β-Casomorphin
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Summary:Abstract Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, ‘near miss SIDS’). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2011.01.005