Association of interleukin-6-572G/C gene polymorphisms in the Cantonese population with intracranial aneurysms

Abstract Recent studies have demonstrated that cytokines play an important role in the pathogenesis of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important proinflammatory cytokine. In our study, we investigated the association of genetic variants within the gene encoding interleukin-6...

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Bibliographic Details
Published in:Journal of the neurological sciences 2011-07, Vol.306 (1), p.94-97
Main Authors: Zhang, Guozhong, Tu, Yanyang, Feng, Wenfeng, Huang, Lijin, Li, Mingzhou, Qi, Songtao
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
Biological and medical sciences
China - ethnology
Female
Gene polymorphism
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Genotype
Humans
Interleukin-6
Interleukin-6 - genetics
Intracranial Aneurysm - genetics
Intracranial aneurysms
Male
Medical sciences
Middle Aged
Neurology
Polymorphism, Single Nucleotide - genetics
Restriction fragment
Vascular diseases and vascular malformations of the nervous system
Young Adult
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Summary:Abstract Recent studies have demonstrated that cytokines play an important role in the pathogenesis of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important proinflammatory cytokine. In our study, we investigated the association of genetic variants within the gene encoding interleukin-6-572G/C (IL-6-572G/C) with IAs in the Cantonese population. The IL-6-572G/C gene polymorphisms in 182 IA cases and 182 controls were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Differences in genotype and allele frequencies between patients and controls were tested. There is significant difference of IL-6-572G/C genotype frequencies in IA group compared with control group (P = 0.01), and significant difference of IL-6-572G/C allele frequency in IA group (11.54%) compared with control group (4.95%) (P = 0.001). Polymorphisms within IL-6-572G/C gene are associated with IAs in the Cantonese population suggesting that the IL-6-572G/C gene is an important candidate gene for IAs.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2011.03.036