Loading…
Efficacy of ultrasound-guided steroid injections for pain management of midfoot joint degenerative disease
Objective To examine the efficacy of ultrasound (US)-guided injections for midfoot joint degenerative changes. Materials and methods The US images and radiographs of 63 patients with midfoot joint degenerative changes were retrospectively reviewed. In those patients who had US-guided intra-articular...
Saved in:
Published in: | Skeletal radiology 2011-08, Vol.40 (8), p.1001-1006 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483 |
---|---|
cites | cdi_FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483 |
container_end_page | 1006 |
container_issue | 8 |
container_start_page | 1001 |
container_title | Skeletal radiology |
container_volume | 40 |
creator | Drakonaki, Eleni E. Kho, James S. B. Sharp, Robert J. Ostlere, Simon J. |
description | Objective
To examine the efficacy of ultrasound (US)-guided injections for midfoot joint degenerative changes.
Materials and methods
The US images and radiographs of 63 patients with midfoot joint degenerative changes were retrospectively reviewed. In those patients who had US-guided intra-articular steroid injection, the response to the injection was recorded by reviewing the 2-week pain diaries and clinical notes. Partial or complete pain relief was defined as a positive response and the same or increased level of pain as a negative response to the injection.
Results
Fifty-nine (59/63, 93.6%) patients with midfoot joint degenerative changes received US-guided injection. The majority of patients had a positive response up to 3 months post-injection (78.4% still experiencing pain relief at 2 weeks, 57.5% at 3 months and fewer than 15% of patients further than 3 months post-injection). The number of positive therapeutic responses did not differ significantly between patients with diagnostic and non-diagnostic response (
p
= 0.2636).
Conclusions
US-guided intra-articular injections for midfoot degenerative changes can have a good therapeutic result in the majority of patients up to 3 months post-injection. Therapeutic response cannot be predicted by a positive diagnostic response. |
doi_str_mv | 10.1007/s00256-010-1094-y |
format | article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_874296577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A730893123</galeid><sourcerecordid>A730893123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EotvCD-CCIhCCS8r4I3FyrKoWkCpxgXPk2OPIq8Re7KTS_nscslCBAPlgefy8r2fGQ8gLCpcUQL5PAKyqS6BQUmhFeXxEdlRwVjJa08dkB7wWJeOiOSPnKe0BqJRV_ZScMcqkkBR2ZH9jrdNKH4tgi2Wco0ph8aYcFmfQFGnGGJwpnN-jnl3wqbAhFgflfDEprwac0M-rdnLGhjAX--BywOCAHqOa3T0WxiVUCZ-RJ1aNCZ-f9gvy9fbmy_XH8u7zh0_XV3elrgDmUtXCUl3rqrFS817rXlrJKytyUFbKWNkzC8wYKvueU1FL1iCH1uRWKCMafkHebr6HGL4tmOZucknjOCqPYUldIwVr60rKTL77L0mBN1XbyEZk9NUf6D4s0ec6Vj_IecgqQ683aFAjds7bkPupV8_uSnJoWk4Zz9TlX6i8DE5OB4_W5fhvAroJdAwpRbTdIbpJxWNOsFsHodsGoYMf51Z0x6x5ecp36Sc0vxQ_fz4Db06ASlqNNiqvXXrgRG5pW6-Fs41L-coPGB8K__fr3wGwlcpV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>874031475</pqid></control><display><type>article</type><title>Efficacy of ultrasound-guided steroid injections for pain management of midfoot joint degenerative disease</title><source>Springer Link</source><creator>Drakonaki, Eleni E. ; Kho, James S. B. ; Sharp, Robert J. ; Ostlere, Simon J.</creator><creatorcontrib>Drakonaki, Eleni E. ; Kho, James S. B. ; Sharp, Robert J. ; Ostlere, Simon J.</creatorcontrib><description>Objective
To examine the efficacy of ultrasound (US)-guided injections for midfoot joint degenerative changes.
Materials and methods
The US images and radiographs of 63 patients with midfoot joint degenerative changes were retrospectively reviewed. In those patients who had US-guided intra-articular steroid injection, the response to the injection was recorded by reviewing the 2-week pain diaries and clinical notes. Partial or complete pain relief was defined as a positive response and the same or increased level of pain as a negative response to the injection.
Results
Fifty-nine (59/63, 93.6%) patients with midfoot joint degenerative changes received US-guided injection. The majority of patients had a positive response up to 3 months post-injection (78.4% still experiencing pain relief at 2 weeks, 57.5% at 3 months and fewer than 15% of patients further than 3 months post-injection). The number of positive therapeutic responses did not differ significantly between patients with diagnostic and non-diagnostic response (
p
= 0.2636).
Conclusions
US-guided intra-articular injections for midfoot degenerative changes can have a good therapeutic result in the majority of patients up to 3 months post-injection. Therapeutic response cannot be predicted by a positive diagnostic response.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-010-1094-y</identifier><identifier>PMID: 21274710</identifier><identifier>CODEN: SKRADI</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adrenal Cortex Hormones - administration & dosage ; Adrenal Cortex Hormones - therapeutic use ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bupivacaine ; Care and treatment ; Diseases of the osteoarticular system ; Female ; Foot Diseases - diagnostic imaging ; Foot Diseases - drug therapy ; Humans ; Imaging ; Injections, Intra-Articular ; Investigative techniques, diagnostic techniques (general aspects) ; Joints ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Nuclear Medicine ; Orthopedics ; Osteoarthritis ; Osteoarthritis - diagnostic imaging ; Osteoarthritis - drug therapy ; Osteoarticular system. Muscles ; Pain ; Pain - drug therapy ; Pain Measurement ; Pathology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiography ; Radiology ; Retrospective Studies ; Scientific Article ; Steroid hormones ; Treatment Outcome ; Ultrasonography, Interventional ; Ultrasound</subject><ispartof>Skeletal radiology, 2011-08, Vol.40 (8), p.1001-1006</ispartof><rights>ISS 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483</citedby><cites>FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24309964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21274710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drakonaki, Eleni E.</creatorcontrib><creatorcontrib>Kho, James S. B.</creatorcontrib><creatorcontrib>Sharp, Robert J.</creatorcontrib><creatorcontrib>Ostlere, Simon J.</creatorcontrib><title>Efficacy of ultrasound-guided steroid injections for pain management of midfoot joint degenerative disease</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Objective
To examine the efficacy of ultrasound (US)-guided injections for midfoot joint degenerative changes.
Materials and methods
The US images and radiographs of 63 patients with midfoot joint degenerative changes were retrospectively reviewed. In those patients who had US-guided intra-articular steroid injection, the response to the injection was recorded by reviewing the 2-week pain diaries and clinical notes. Partial or complete pain relief was defined as a positive response and the same or increased level of pain as a negative response to the injection.
Results
Fifty-nine (59/63, 93.6%) patients with midfoot joint degenerative changes received US-guided injection. The majority of patients had a positive response up to 3 months post-injection (78.4% still experiencing pain relief at 2 weeks, 57.5% at 3 months and fewer than 15% of patients further than 3 months post-injection). The number of positive therapeutic responses did not differ significantly between patients with diagnostic and non-diagnostic response (
p
= 0.2636).
Conclusions
US-guided intra-articular injections for midfoot degenerative changes can have a good therapeutic result in the majority of patients up to 3 months post-injection. Therapeutic response cannot be predicted by a positive diagnostic response.</description><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bupivacaine</subject><subject>Care and treatment</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Foot Diseases - diagnostic imaging</subject><subject>Foot Diseases - drug therapy</subject><subject>Humans</subject><subject>Imaging</subject><subject>Injections, Intra-Articular</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Joints</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Osteoarthritis - drug therapy</subject><subject>Osteoarticular system. Muscles</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement</subject><subject>Pathology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiography</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Scientific Article</subject><subject>Steroid hormones</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Interventional</subject><subject>Ultrasound</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kk1v1DAQhi0EotvCD-CCIhCCS8r4I3FyrKoWkCpxgXPk2OPIq8Re7KTS_nscslCBAPlgefy8r2fGQ8gLCpcUQL5PAKyqS6BQUmhFeXxEdlRwVjJa08dkB7wWJeOiOSPnKe0BqJRV_ZScMcqkkBR2ZH9jrdNKH4tgi2Wco0ph8aYcFmfQFGnGGJwpnN-jnl3wqbAhFgflfDEprwac0M-rdnLGhjAX--BywOCAHqOa3T0WxiVUCZ-RJ1aNCZ-f9gvy9fbmy_XH8u7zh0_XV3elrgDmUtXCUl3rqrFS817rXlrJKytyUFbKWNkzC8wYKvueU1FL1iCH1uRWKCMafkHebr6HGL4tmOZucknjOCqPYUldIwVr60rKTL77L0mBN1XbyEZk9NUf6D4s0ec6Vj_IecgqQ683aFAjds7bkPupV8_uSnJoWk4Zz9TlX6i8DE5OB4_W5fhvAroJdAwpRbTdIbpJxWNOsFsHodsGoYMf51Z0x6x5ecp36Sc0vxQ_fz4Db06ASlqNNiqvXXrgRG5pW6-Fs41L-coPGB8K__fr3wGwlcpV</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Drakonaki, Eleni E.</creator><creator>Kho, James S. B.</creator><creator>Sharp, Robert J.</creator><creator>Ostlere, Simon J.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Efficacy of ultrasound-guided steroid injections for pain management of midfoot joint degenerative disease</title><author>Drakonaki, Eleni E. ; Kho, James S. B. ; Sharp, Robert J. ; Ostlere, Simon J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bupivacaine</topic><topic>Care and treatment</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Foot Diseases - diagnostic imaging</topic><topic>Foot Diseases - drug therapy</topic><topic>Humans</topic><topic>Imaging</topic><topic>Injections, Intra-Articular</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Joints</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Osteoarthritis - drug therapy</topic><topic>Osteoarticular system. Muscles</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement</topic><topic>Pathology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiography</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Scientific Article</topic><topic>Steroid hormones</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Interventional</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drakonaki, Eleni E.</creatorcontrib><creatorcontrib>Kho, James S. B.</creatorcontrib><creatorcontrib>Sharp, Robert J.</creatorcontrib><creatorcontrib>Ostlere, Simon J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drakonaki, Eleni E.</au><au>Kho, James S. B.</au><au>Sharp, Robert J.</au><au>Ostlere, Simon J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of ultrasound-guided steroid injections for pain management of midfoot joint degenerative disease</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>40</volume><issue>8</issue><spage>1001</spage><epage>1006</epage><pages>1001-1006</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><coden>SKRADI</coden><abstract>Objective
To examine the efficacy of ultrasound (US)-guided injections for midfoot joint degenerative changes.
Materials and methods
The US images and radiographs of 63 patients with midfoot joint degenerative changes were retrospectively reviewed. In those patients who had US-guided intra-articular steroid injection, the response to the injection was recorded by reviewing the 2-week pain diaries and clinical notes. Partial or complete pain relief was defined as a positive response and the same or increased level of pain as a negative response to the injection.
Results
Fifty-nine (59/63, 93.6%) patients with midfoot joint degenerative changes received US-guided injection. The majority of patients had a positive response up to 3 months post-injection (78.4% still experiencing pain relief at 2 weeks, 57.5% at 3 months and fewer than 15% of patients further than 3 months post-injection). The number of positive therapeutic responses did not differ significantly between patients with diagnostic and non-diagnostic response (
p
= 0.2636).
Conclusions
US-guided intra-articular injections for midfoot degenerative changes can have a good therapeutic result in the majority of patients up to 3 months post-injection. Therapeutic response cannot be predicted by a positive diagnostic response.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21274710</pmid><doi>10.1007/s00256-010-1094-y</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0364-2348 |
ispartof | Skeletal radiology, 2011-08, Vol.40 (8), p.1001-1006 |
issn | 0364-2348 1432-2161 |
language | eng |
recordid | cdi_proquest_miscellaneous_874296577 |
source | Springer Link |
subjects | Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Aged Aged, 80 and over Biological and medical sciences Bupivacaine Care and treatment Diseases of the osteoarticular system Female Foot Diseases - diagnostic imaging Foot Diseases - drug therapy Humans Imaging Injections, Intra-Articular Investigative techniques, diagnostic techniques (general aspects) Joints Male Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Nuclear Medicine Orthopedics Osteoarthritis Osteoarthritis - diagnostic imaging Osteoarthritis - drug therapy Osteoarticular system. Muscles Pain Pain - drug therapy Pain Measurement Pathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiography Radiology Retrospective Studies Scientific Article Steroid hormones Treatment Outcome Ultrasonography, Interventional Ultrasound |
title | Efficacy of ultrasound-guided steroid injections for pain management of midfoot joint degenerative disease |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T22%3A47%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20ultrasound-guided%20steroid%20injections%20for%20pain%20management%20of%20midfoot%20joint%20degenerative%20disease&rft.jtitle=Skeletal%20radiology&rft.au=Drakonaki,%20Eleni%20E.&rft.date=2011-08-01&rft.volume=40&rft.issue=8&rft.spage=1001&rft.epage=1006&rft.pages=1001-1006&rft.issn=0364-2348&rft.eissn=1432-2161&rft.coden=SKRADI&rft_id=info:doi/10.1007/s00256-010-1094-y&rft_dat=%3Cgale_proqu%3EA730893123%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c500t-a64f1c6c58f7c3bccb7f735f41c675adf7b2f02dd17bb3146728e309d256ad483%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=874031475&rft_id=info:pmid/21274710&rft_galeid=A730893123&rfr_iscdi=true |