Erectile Dysfunction and Risk of Clinical Cardiovascular Events: A Meta-Analysis of Seven Cohort Studies

For many years, erectile dysfunction (ED) has been considered as a complication of cardiovascular disease (CVD) or regarded as a late consequence of generalized arterial disease. However, a growing body of evidence suggests that ED is an early manifestation of atherosclerosis and a precursor to syst...

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Bibliographic Details
Published in:Journal of sexual medicine 2010-08, Vol.7 (8), p.2805-2816
Main Authors: Guo, Wenbin, Liao, Cun, Zou, Yaguang, Li, Fei, Li, Tieqiu, Zhou, Qizhao, Cao, Yunfei, Mao, Xiangming
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
All-Cause Mortality
Cardiovascular Disease Events
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cause of Death
Cohort Studies
Coronary Artery Disease - diagnosis
Coronary Artery Disease - epidemiology
Coronary Artery Disease - mortality
Endothelial Dysfunction
Erectile Dysfunction
Follow-Up Studies
Humans
Impotence, Vasculogenic - diagnosis
Impotence, Vasculogenic - epidemiology
Impotence, Vasculogenic - mortality
Male
Meta-Analysis
Middle Aged
Myocardial Infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Myocardial Infarction - mortality
Risk
Young Adult
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Summary:For many years, erectile dysfunction (ED) has been considered as a complication of cardiovascular disease (CVD) or regarded as a late consequence of generalized arterial disease. However, a growing body of evidence suggests that ED is an early manifestation of atherosclerosis and a precursor to systemic vascular disease. We conducted a meta-analysis to evaluate the association between ED and the risk of CVD events. Relevant studies published between January 1966 and September 2009 were identified by searching Medline, Embase, and The Cochrane Library. Studies were selected using a prior defined criteria. The strength of the relationship between ED and CVD events was assessed by adjusted relative risks (RRs). The adjusted RRs of CVD events. A total of 45,558 participants from seven cohort studies (eight full-text articles) were identified in this meta-analysis. The studies provided adjusted RRs estimates for ED subjects comparing with health subjects, leading to a pooled adjusted RR of 1.47 (95% confidence interval [CI], 1.29–1.66, P
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2010.01792.x