CuBr catalyzed C-N cross coupling reaction of purines and diaryliodonium salts to 9-arylpurines

CuBr was found to be an efficient catalyst for the C-N cross coupling reaction of purine and diaryliodonium salts. 9-Arylpurines were synthesized in excellent yields with short reaction times (2.5 h). The method represents an alternative to the synthesis of 9-arylpurines via Cu(II) catalyzed C-N cou...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2011-01, Vol.9 (14), p.5039-5042
Main Authors: Niu, Hong-Ying, Xia, Chao, Qu, Gui-Rong, Zhang, Qian, Jiang, Yi, Mao, Run-Ze, Li, De-Yang, Guo, Hai-Ming
Format: Article
Language:English
Subjects:
Acids
Bromides - chemistry
Catalysis
Copper - chemistry
Crystallography, X-Ray
Hydrocarbons, Iodinated - chemistry
Models, Molecular
Molecular Structure
Purines - chemical synthesis
Purines - chemistry
Salts - chemistry
Stereoisomerism
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Summary:CuBr was found to be an efficient catalyst for the C-N cross coupling reaction of purine and diaryliodonium salts. 9-Arylpurines were synthesized in excellent yields with short reaction times (2.5 h). The method represents an alternative to the synthesis of 9-arylpurines via Cu(II) catalyzed C-N coupling reaction with arylboronic acids as arylating agents.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob05333g