Rational Molecular Design of Stimulus-Responsive Supramolecular Hydrogels Based on Dipeptides

Stimuli‐responsive supramolecular hydro­gels comprising self‐assembled nanofiber networks are attractive soft materials because of their potential application in materials science and bionanotechnology. Here, we describe a general strategy for the rational design of stimuli (redox‐ or photo‐)respons...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2011-07, Vol.23 (25), p.2819-2822
Main Authors: Ikeda, Masato, Tanida, Tatsuya, Yoshii, Tatsuyuki, Hamachi, Itaru
Format: Article
Language:English
Subjects:
Dipeptides - chemistry
drug release
hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Macromolecular Substances - chemical synthesis
Macromolecular Substances - chemistry
Materials Testing
Molecular Structure
Particle Size
peptides
self-assembly
stimuli-responsive materials
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stimuli‐responsive supramolecular hydro­gels comprising self‐assembled nanofiber networks are attractive soft materials because of their potential application in materials science and bionanotechnology. Here, we describe a general strategy for the rational design of stimuli (redox‐ or photo‐)responsive supramolecular hydrogelators by introducing stimuli‐triggered degradation units into the N‐terminal of a dipeptide. We also demonstrate that its coupling with glucose oxidase allows us to produce a glucose‐responsive insulin‐releasing gel matrix.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201004658