Loading…

Second- and third-generation drug-eluting coronary stents: Progress and safety

Drug-eluting stents (DES) have revolutionized the treatment of coronary artery disease by reducing the rate of in-stent restenosis from 20–40% with bare-metal stent (BMS) to 6–8% with DES. However, with widespread use of DES, safety concerns have risen due to the observation of late stent thrombosis...

Full description

Saved in:
Bibliographic Details
Published in:Herz 2011-05, Vol.36 (3), p.190-197
Main Authors: Akin, I., Schneider, H., Ince, H., Kische, S., Rehders, T.C., Chatterjee, T., Nienaber, C.A.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c276z-fbb6e5ea6c3a5e57aa5bb8f0c434bf868a59120ffaa2c2c4650c8f5fca00c6693
container_end_page 197
container_issue 3
container_start_page 190
container_title Herz
container_volume 36
creator Akin, I.
Schneider, H.
Ince, H.
Kische, S.
Rehders, T.C.
Chatterjee, T.
Nienaber, C.A.
description Drug-eluting stents (DES) have revolutionized the treatment of coronary artery disease by reducing the rate of in-stent restenosis from 20–40% with bare-metal stent (BMS) to 6–8% with DES. However, with widespread use of DES, safety concerns have risen due to the observation of late stent thrombosis. With this in mind and better understanding of mechanism and pathophysiology of stent thrombosis, the technological platform, especially innovative anti-restenotic agents, polymeric coatings, and stent platforms, improved with newer DES. Two second-generation DES, the Endeavor zotarolimus-eluting stent (ZES) and the Xience-V everolimus-eluting stent (EES), have provided promising results in both randomized controlled trials (SPIRIT and ENDEAVOR) and registries (E-Five, COMPARE) compared with bare-metal stents (BMS) and first-generation DES. Newer third-generation stent technology, especially biodegradable polymers, polymer-free stents, and biodegradable stents on the basis of poly-L-lactide (PLLA) or magnesium, has been evaluated in preclinical and initial clinical trials. However, despite encouraging initial results, long-term data of large-scale randomized trials as well as registries comparing them to currently approved first- and second-generation DES are still lacking.
doi_str_mv 10.1007/s00059-011-3458-z
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_874486577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>874486577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c276z-fbb6e5ea6c3a5e57aa5bb8f0c434bf868a59120ffaa2c2c4650c8f5fca00c6693</originalsourceid><addsrcrecordid>eNp9kLFOwzAQhi0EoqXwACwoG5Ph7NhOMqKKAlIlBmC2HMcOqVK72MlAnx5XKYxMN9z3_7r7ELomcEcAivsIALzCQAjOGS_x_gTNiSAcC1HRUzSHnAGuqryYoYsYNwCEVxTO0YwSnoI5m6PqzWjvGpwp12TDZxca3Bpngho677ImjC02_Th0rs20D96p8J3FwbghXqIzq_poro5zgT5Wj-_LZ7x-fXpZPqyxpoXYY1vXwnCjhM4VN7xQitd1aUGznNW2FKXiFaFgrVJUU80EB11abrUC0OmPfIFup95d8F-jiYPcdlGbvlfO-DHKsmCsFLwoEkkmUgcfYzBW7kK3TRdLAvIgTE7CZBImD8LkPmVuju1jvTXNX-LXUALoBMS0cq0JcuPH4NLH_7T-APUWd0I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>874486577</pqid></control><display><type>article</type><title>Second- and third-generation drug-eluting coronary stents: Progress and safety</title><source>Springer Nature</source><creator>Akin, I. ; Schneider, H. ; Ince, H. ; Kische, S. ; Rehders, T.C. ; Chatterjee, T. ; Nienaber, C.A.</creator><creatorcontrib>Akin, I. ; Schneider, H. ; Ince, H. ; Kische, S. ; Rehders, T.C. ; Chatterjee, T. ; Nienaber, C.A.</creatorcontrib><description>Drug-eluting stents (DES) have revolutionized the treatment of coronary artery disease by reducing the rate of in-stent restenosis from 20–40% with bare-metal stent (BMS) to 6–8% with DES. However, with widespread use of DES, safety concerns have risen due to the observation of late stent thrombosis. With this in mind and better understanding of mechanism and pathophysiology of stent thrombosis, the technological platform, especially innovative anti-restenotic agents, polymeric coatings, and stent platforms, improved with newer DES. Two second-generation DES, the Endeavor zotarolimus-eluting stent (ZES) and the Xience-V everolimus-eluting stent (EES), have provided promising results in both randomized controlled trials (SPIRIT and ENDEAVOR) and registries (E-Five, COMPARE) compared with bare-metal stents (BMS) and first-generation DES. Newer third-generation stent technology, especially biodegradable polymers, polymer-free stents, and biodegradable stents on the basis of poly-L-lactide (PLLA) or magnesium, has been evaluated in preclinical and initial clinical trials. However, despite encouraging initial results, long-term data of large-scale randomized trials as well as registries comparing them to currently approved first- and second-generation DES are still lacking.</description><identifier>ISSN: 0340-9937</identifier><identifier>EISSN: 1615-6692</identifier><identifier>DOI: 10.1007/s00059-011-3458-z</identifier><identifier>PMID: 21505934</identifier><language>eng</language><publisher>Munchen: Urban and Vogel</publisher><subject>Cardiology ; Coronary Artery Disease - drug therapy ; Coronary Restenosis - etiology ; Coronary Restenosis - prevention &amp; control ; Drug-Eluting Stents - adverse effects ; Drug-Eluting Stents - trends ; Fibrinolytic Agents - therapeutic use ; Forecasting ; Graft Occlusion, Vascular - etiology ; Graft Occlusion, Vascular - prevention &amp; control ; Humans ; Internal Medicine ; Main topic/CME ; Medicine ; Medicine &amp; Public Health</subject><ispartof>Herz, 2011-05, Vol.36 (3), p.190-197</ispartof><rights>Urban &amp; Vogel, Muenchen 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276z-fbb6e5ea6c3a5e57aa5bb8f0c434bf868a59120ffaa2c2c4650c8f5fca00c6693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21505934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akin, I.</creatorcontrib><creatorcontrib>Schneider, H.</creatorcontrib><creatorcontrib>Ince, H.</creatorcontrib><creatorcontrib>Kische, S.</creatorcontrib><creatorcontrib>Rehders, T.C.</creatorcontrib><creatorcontrib>Chatterjee, T.</creatorcontrib><creatorcontrib>Nienaber, C.A.</creatorcontrib><title>Second- and third-generation drug-eluting coronary stents: Progress and safety</title><title>Herz</title><addtitle>Herz</addtitle><addtitle>Herz</addtitle><description>Drug-eluting stents (DES) have revolutionized the treatment of coronary artery disease by reducing the rate of in-stent restenosis from 20–40% with bare-metal stent (BMS) to 6–8% with DES. However, with widespread use of DES, safety concerns have risen due to the observation of late stent thrombosis. With this in mind and better understanding of mechanism and pathophysiology of stent thrombosis, the technological platform, especially innovative anti-restenotic agents, polymeric coatings, and stent platforms, improved with newer DES. Two second-generation DES, the Endeavor zotarolimus-eluting stent (ZES) and the Xience-V everolimus-eluting stent (EES), have provided promising results in both randomized controlled trials (SPIRIT and ENDEAVOR) and registries (E-Five, COMPARE) compared with bare-metal stents (BMS) and first-generation DES. Newer third-generation stent technology, especially biodegradable polymers, polymer-free stents, and biodegradable stents on the basis of poly-L-lactide (PLLA) or magnesium, has been evaluated in preclinical and initial clinical trials. However, despite encouraging initial results, long-term data of large-scale randomized trials as well as registries comparing them to currently approved first- and second-generation DES are still lacking.</description><subject>Cardiology</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Coronary Restenosis - etiology</subject><subject>Coronary Restenosis - prevention &amp; control</subject><subject>Drug-Eluting Stents - adverse effects</subject><subject>Drug-Eluting Stents - trends</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Forecasting</subject><subject>Graft Occlusion, Vascular - etiology</subject><subject>Graft Occlusion, Vascular - prevention &amp; control</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Main topic/CME</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><issn>0340-9937</issn><issn>1615-6692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOwzAQhi0EoqXwACwoG5Ph7NhOMqKKAlIlBmC2HMcOqVK72MlAnx5XKYxMN9z3_7r7ELomcEcAivsIALzCQAjOGS_x_gTNiSAcC1HRUzSHnAGuqryYoYsYNwCEVxTO0YwSnoI5m6PqzWjvGpwp12TDZxca3Bpngho677ImjC02_Th0rs20D96p8J3FwbghXqIzq_poro5zgT5Wj-_LZ7x-fXpZPqyxpoXYY1vXwnCjhM4VN7xQitd1aUGznNW2FKXiFaFgrVJUU80EB11abrUC0OmPfIFup95d8F-jiYPcdlGbvlfO-DHKsmCsFLwoEkkmUgcfYzBW7kK3TRdLAvIgTE7CZBImD8LkPmVuju1jvTXNX-LXUALoBMS0cq0JcuPH4NLH_7T-APUWd0I</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Akin, I.</creator><creator>Schneider, H.</creator><creator>Ince, H.</creator><creator>Kische, S.</creator><creator>Rehders, T.C.</creator><creator>Chatterjee, T.</creator><creator>Nienaber, C.A.</creator><general>Urban and Vogel</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>Second- and third-generation drug-eluting coronary stents</title><author>Akin, I. ; Schneider, H. ; Ince, H. ; Kische, S. ; Rehders, T.C. ; Chatterjee, T. ; Nienaber, C.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276z-fbb6e5ea6c3a5e57aa5bb8f0c434bf868a59120ffaa2c2c4650c8f5fca00c6693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Cardiology</topic><topic>Coronary Artery Disease - drug therapy</topic><topic>Coronary Restenosis - etiology</topic><topic>Coronary Restenosis - prevention &amp; control</topic><topic>Drug-Eluting Stents - adverse effects</topic><topic>Drug-Eluting Stents - trends</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Forecasting</topic><topic>Graft Occlusion, Vascular - etiology</topic><topic>Graft Occlusion, Vascular - prevention &amp; control</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Main topic/CME</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akin, I.</creatorcontrib><creatorcontrib>Schneider, H.</creatorcontrib><creatorcontrib>Ince, H.</creatorcontrib><creatorcontrib>Kische, S.</creatorcontrib><creatorcontrib>Rehders, T.C.</creatorcontrib><creatorcontrib>Chatterjee, T.</creatorcontrib><creatorcontrib>Nienaber, C.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Herz</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akin, I.</au><au>Schneider, H.</au><au>Ince, H.</au><au>Kische, S.</au><au>Rehders, T.C.</au><au>Chatterjee, T.</au><au>Nienaber, C.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second- and third-generation drug-eluting coronary stents: Progress and safety</atitle><jtitle>Herz</jtitle><stitle>Herz</stitle><addtitle>Herz</addtitle><date>2011-05</date><risdate>2011</risdate><volume>36</volume><issue>3</issue><spage>190</spage><epage>197</epage><pages>190-197</pages><issn>0340-9937</issn><eissn>1615-6692</eissn><abstract>Drug-eluting stents (DES) have revolutionized the treatment of coronary artery disease by reducing the rate of in-stent restenosis from 20–40% with bare-metal stent (BMS) to 6–8% with DES. However, with widespread use of DES, safety concerns have risen due to the observation of late stent thrombosis. With this in mind and better understanding of mechanism and pathophysiology of stent thrombosis, the technological platform, especially innovative anti-restenotic agents, polymeric coatings, and stent platforms, improved with newer DES. Two second-generation DES, the Endeavor zotarolimus-eluting stent (ZES) and the Xience-V everolimus-eluting stent (EES), have provided promising results in both randomized controlled trials (SPIRIT and ENDEAVOR) and registries (E-Five, COMPARE) compared with bare-metal stents (BMS) and first-generation DES. Newer third-generation stent technology, especially biodegradable polymers, polymer-free stents, and biodegradable stents on the basis of poly-L-lactide (PLLA) or magnesium, has been evaluated in preclinical and initial clinical trials. However, despite encouraging initial results, long-term data of large-scale randomized trials as well as registries comparing them to currently approved first- and second-generation DES are still lacking.</abstract><cop>Munchen</cop><pub>Urban and Vogel</pub><pmid>21505934</pmid><doi>10.1007/s00059-011-3458-z</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0340-9937
ispartof Herz, 2011-05, Vol.36 (3), p.190-197
issn 0340-9937
1615-6692
language eng
recordid cdi_proquest_miscellaneous_874486577
source Springer Nature
subjects Cardiology
Coronary Artery Disease - drug therapy
Coronary Restenosis - etiology
Coronary Restenosis - prevention & control
Drug-Eluting Stents - adverse effects
Drug-Eluting Stents - trends
Fibrinolytic Agents - therapeutic use
Forecasting
Graft Occlusion, Vascular - etiology
Graft Occlusion, Vascular - prevention & control
Humans
Internal Medicine
Main topic/CME
Medicine
Medicine & Public Health
title Second- and third-generation drug-eluting coronary stents: Progress and safety
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A44%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Second-%20and%20third-generation%20drug-eluting%20coronary%20stents:%20Progress%20and%20safety&rft.jtitle=Herz&rft.au=Akin,%20I.&rft.date=2011-05&rft.volume=36&rft.issue=3&rft.spage=190&rft.epage=197&rft.pages=190-197&rft.issn=0340-9937&rft.eissn=1615-6692&rft_id=info:doi/10.1007/s00059-011-3458-z&rft_dat=%3Cproquest_cross%3E874486577%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c276z-fbb6e5ea6c3a5e57aa5bb8f0c434bf868a59120ffaa2c2c4650c8f5fca00c6693%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=874486577&rft_id=info:pmid/21505934&rfr_iscdi=true