Adult intensive-care patients with 2009 pandemic influenza A(H1N1) infection

In France, the surveillance of hospitalized cases of pandemic influenza was implemented in July 2009 and restricted to intensive-care unit (ICU) patients in November. We described the characteristics of the 1065 adult patients admitted to ICUs and analysed risk factors for severe outcome (mechanical...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2011-08, Vol.139 (8), p.1202-1209
Main Authors: FUHRMAN, C., BONMARIN, I., BITAR, D., CARDOSO, T., DUPORT, N., HERIDA, M., ISNARD, H., GUIDET, B., MIMOZ, O., RICHARD, J. C. M., BRUN-BUISSON, C., BROCHARD, L., MAILLES, A., PATY, A. C., SAURA, C., LÉVY-BRUHL, D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Age
Age Factors
Aged
Aged, 80 and over
Antiviral Agents - administration & dosage
Antivirals
Asthma
Biological and medical sciences
Body mass index
Critical Care
Death
Diabetes
Disease risk
Family physicians
Fatalities
Female
France
Fundamental and applied biological sciences. Psychology
Hospitalization
Hospitals
Humans
Influenza
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza, Human - drug therapy
Influenza, Human - mortality
Influenza, Human - pathology
Influenza, Human - virology
Intensive care units
Laboratories
Male
Microbiology
Middle Aged
Mortality
Obesity
Obesity - complications
Pandemics
Patient admissions
Predisposing factors
Pregnancy
Respiratory diseases
Risk Factors
Swine flu
Time Factors
Variables
Viruses
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In France, the surveillance of hospitalized cases of pandemic influenza was implemented in July 2009 and restricted to intensive-care unit (ICU) patients in November. We described the characteristics of the 1065 adult patients admitted to ICUs and analysed risk factors for severe outcome (mechanical ventilation or death). Eighty-seven percent of cases were aged 15–64 years. The case-fatality ratio was 20%. The risk for severe outcome increased with age and obesity while this association was negative for chronic respiratory disease. Late antiviral therapy was associated with a severe outcome in ICU patients with risk factors (adjusted OR 2·0, 95% CI 1·4–3·0). This study confirms the considerable contribution of young adults to A(H1N1) 2009 mortality. It shows the role of obesity as an independent risk factor for severe disease, and of early antiviral therapy as a protective factor, at least in patients with risk factors.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268810002414