Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agent...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (14), p.4138-4140
Main Authors: Nagarapu, Lingaiah, Mateti, Jhansi, Gaikwad, Hanmant K, Bantu, Rajashaker, Sheeba Rani, M, Prameela Subhashini, N.J
Format: Article
Language:English
Subjects:
Amides - chemical synthesis
Amides - chemistry
Amides - therapeutic use
Animals
anti-inflammatory activity
anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Carrageenan - toxicity
chemistry
edema
Edema - chemically induced
Edema - drug therapy
Medical sciences
Pharmacology. Drug treatments
Pyrazoles - chemistry
Rats
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Summary:A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.05.105