Weighting Restriction for Intravenous Insulin Delivery on T1DM Patient via H infty Control

A weighting restriction with frequency components is proposed for the insulin delivery on Type 1 Diabetics Mellitus (T1DM) towards the control of the blood glucose level. The weighting restriction is stated from a model of healthy subjects which includes a rate for insulin delivery. The frequency co...

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Bibliographic Details
Published in:IEEE transactions on automation science and engineering 2009-01, Vol.6 (2)
Main Authors: Femat, R, Ruiz-Velazquez, E, Quiroz, G
Format: Article
Language:English
Subjects:
Actuators
Constrictions
Control systems
Dynamical systems
Glucose
Inclusions
Insulin
Weighting
Online Access:Get full text
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Summary:A weighting restriction with frequency components is proposed for the insulin delivery on Type 1 Diabetics Mellitus (T1DM) towards the control of the blood glucose level. The weighting restriction is stated from a model of healthy subjects which includes a rate for insulin delivery. The frequency components are incorporated via a transfer function from the plasma glucose to the free-plasma insulin such that a H sub(infin)-based controller is designed. In this way, the control synthesis involves the frequency components on which a healthy pancreas delivers insulin for the glucose homeostasis. In order to test controller performance, a dynamical model of an actuator is also included in the closed-loop system to add its effects in the closed-loop evaluation of the H sub(infin) -based controller. The actuator is a pump to deliver of an insulin infusion according with the rate computed by the controller. Note that the contribution is particularly focused on T1DM; however, the inclusion of weighting restriction can be used also onto critical care conditions.
ISSN:1545-5955
DOI:10.1109/TASE.2008.2009089