Early determinants of atherosclerosis in paediatric systemic lupus erythematosus

To assess traditional and non-traditional cardiovascular risk factors and to determine the prevalence and correlates of early vascular markers of atherosclerosis in paediatric systemic lupus erythematosus (pSLE). Fifty-four adolescents with pSLE had cardiovascular risk factor assessment, disease act...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2011-05, Vol.29 (3), p.575-581
Main Authors: BOROS, C. A, BRADLEY, T. J, CHEUNG, M. M. H, BARGMAN, J. M, RUSSELL, J. L, MCCRINDLE, B. W, ADELI, K, HAMILTON, J, SILVERMAN, E. D
Format: Article
Language:English
Subjects:
Adolescent
Apolipoproteins B - blood
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - diagnosis
Atherosclerosis - epidemiology
Atherosclerosis - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiology
Case-Control Studies
Child
Diseases of the osteoarticular system
Elasticity - physiology
Female
Glycated Hemoglobin A - metabolism
Humans
Insulin Resistance - physiology
Lupus Erythematosus, Systemic - complications
Male
Medical sciences
Prevalence
Regional Blood Flow - physiology
Retrospective Studies
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Triglycerides - blood
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography
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Summary:To assess traditional and non-traditional cardiovascular risk factors and to determine the prevalence and correlates of early vascular markers of atherosclerosis in paediatric systemic lupus erythematosus (pSLE). Fifty-four adolescents with pSLE had cardiovascular risk factor assessment, disease activity and vascular testing including carotid intima-media thickness (CIMT), flow-mediated dilatation (FMD), arterial stiffness measures, and myocardial perfusion studies. The traditional risk factors of hypertension, elevated triglycerides, apolipoprotein B, haemoglobin A1c and insulin levels and non-traditional risk factors of elevated homocysteine and fibrinogen were present (all p
ISSN:0392-856X
1593-098X