Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease

• Published in: Clinical endocrinology (Oxford) 2011-08, Vol.75 (2), p.189-195
• Main Authors: Pirgon, Ozgur, Bilgin, Huseyin, Tolu, Ismet, Odabas, Dursun
• Format: Article
• Language: English
• Subjects: Adolescent; Biological and medical sciences; Bone Density; Calcification, Physiologic; Case-Control Studies; Child; Endocrinopathies; Fatty Liver - complications; Fatty Liver - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Humans; Insulin Resistance; Male; Medical sciences; Metabolic diseases; Non-alcoholic Fatty Liver Disease; Obesity; Obesity - complications; Obesity - physiopathology; Risk Factors; Vertebrates: endocrinology
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/j.1365-2265.2011.04038.x

Summary Aim  The aim of this study was to investigate the relationships between bone mineral density (BMD) vs insulin resistance and metabolic risk factors in obese adolescents with nonalcoholic fatty liver disease (NAFLD). Patients and methods  Eighty‐two obese adolescents [45 girls and 37 boys, mean age: 12·3 ± 1·7 years, mean body mass index‐standard deviation score (BMI‐SDS): 1·9 ± 0·2] and 30 control subjects (15 girls and 15 boys, mean age: 12·3 ± 1·45 years, mean BMI‐SDS: 0·5 ± 0·7) were enrolled the study. The obese subjects were divided into two groups based on the presence or absence of liver steatosis with high transaminases (NAFLD group and non‐NAFLD group). Insulin resistance was evaluated by homeostasis model assessment (HOMA‐IR) from fasting samples. BMD was determined by dual‐energy X‐ray absorptiometry. Results  Fasting insulin levels in the NAFLD group were significantly higher than in the non‐NAFLD obese (32·3 ± 24·0 vs 11·02 ± 2·95 mU/l, P < 0·001) and control groups (8·4 ± 2·4 mU/l, P< 0·001). The NAFLD group had higher values of HOMA‐IR than the non‐NAFLD obese (7·3 ± 0·1 vs 2·3 ± 0·7, P < 0·001) and control groups (1·8 ± 0·5, P