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Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease
Summary Aim The aim of this study was to investigate the relationships between bone mineral density (BMD) vs insulin resistance and metabolic risk factors in obese adolescents with nonalcoholic fatty liver disease (NAFLD). Patients and methods Eighty‐two obese adolescents [45 girls and 37 boys, me...
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| Published in: | Clinical endocrinology (Oxford) 2011-08, Vol.75 (2), p.189-195 |
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| creator | Pirgon, Ozgur Bilgin, Huseyin Tolu, Ismet Odabas, Dursun |
| description | Summary
Aim The aim of this study was to investigate the relationships between bone mineral density (BMD) vs insulin resistance and metabolic risk factors in obese adolescents with nonalcoholic fatty liver disease (NAFLD).
Patients and methods Eighty‐two obese adolescents [45 girls and 37 boys, mean age: 12·3 ± 1·7 years, mean body mass index‐standard deviation score (BMI‐SDS): 1·9 ± 0·2] and 30 control subjects (15 girls and 15 boys, mean age: 12·3 ± 1·45 years, mean BMI‐SDS: 0·5 ± 0·7) were enrolled the study. The obese subjects were divided into two groups based on the presence or absence of liver steatosis with high transaminases (NAFLD group and non‐NAFLD group). Insulin resistance was evaluated by homeostasis model assessment (HOMA‐IR) from fasting samples. BMD was determined by dual‐energy X‐ray absorptiometry.
Results Fasting insulin levels in the NAFLD group were significantly higher than in the non‐NAFLD obese (32·3 ± 24·0 vs 11·02 ± 2·95 mU/l, P < 0·001) and control groups (8·4 ± 2·4 mU/l, P< 0·001). The NAFLD group had higher values of HOMA‐IR than the non‐NAFLD obese (7·3 ± 0·1 vs 2·3 ± 0·7, P < 0·001) and control groups (1·8 ± 0·5, P |
| doi_str_mv | 10.1111/j.1365-2265.2011.04038.x |
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Aim The aim of this study was to investigate the relationships between bone mineral density (BMD) vs insulin resistance and metabolic risk factors in obese adolescents with nonalcoholic fatty liver disease (NAFLD).
Patients and methods Eighty‐two obese adolescents [45 girls and 37 boys, mean age: 12·3 ± 1·7 years, mean body mass index‐standard deviation score (BMI‐SDS): 1·9 ± 0·2] and 30 control subjects (15 girls and 15 boys, mean age: 12·3 ± 1·45 years, mean BMI‐SDS: 0·5 ± 0·7) were enrolled the study. The obese subjects were divided into two groups based on the presence or absence of liver steatosis with high transaminases (NAFLD group and non‐NAFLD group). Insulin resistance was evaluated by homeostasis model assessment (HOMA‐IR) from fasting samples. BMD was determined by dual‐energy X‐ray absorptiometry.
Results Fasting insulin levels in the NAFLD group were significantly higher than in the non‐NAFLD obese (32·3 ± 24·0 vs 11·02 ± 2·95 mU/l, P < 0·001) and control groups (8·4 ± 2·4 mU/l, P< 0·001). The NAFLD group had higher values of HOMA‐IR than the non‐NAFLD obese (7·3 ± 0·1 vs 2·3 ± 0·7, P < 0·001) and control groups (1·8 ± 0·5, P < 0·001). BMD‐SDS measurements were lower in the NAFLD group than in the non‐NAFLD (0·56 ± 0·3 vs 1·02 ± 0·9, P < 0·001) and control groups (0·56 ± 0·3 vs 1·37 ± 1·04, P < 0·001). BMD‐SDS was positively correlated with BMI‐SDS (r = 0·530, P = 0·004) and negatively correlated with HOMA‐IR (r = −0·628, P = 0·017) in the NAFLD obese group.
Conclusion This study reports the association between BMD‐SDS and insulin resistance in obese adolescents both with and without NAFLD, although the NAFLD group had a lower BMD‐SDS than the non‐NAFLD group. We suggest that NAFLD has a detrimental effect on bone health in adolescents, and it is correlated with increased insulin resistance.]]></description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2011.04038.x</identifier><identifier>PMID: 21521307</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Bone Density ; Calcification, Physiologic ; Case-Control Studies ; Child ; Endocrinopathies ; Fatty Liver - complications ; Fatty Liver - physiopathology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Insulin Resistance ; Male ; Medical sciences ; Metabolic diseases ; Non-alcoholic Fatty Liver Disease ; Obesity ; Obesity - complications ; Obesity - physiopathology ; Risk Factors ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2011-08, Vol.75 (2), p.189-195</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4488-6c206de592ead9e2ebf5cc00bf7a0b0047bb331f5a64d472bfb7707b05c74a623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24306256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21521307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pirgon, Ozgur</creatorcontrib><creatorcontrib>Bilgin, Huseyin</creatorcontrib><creatorcontrib>Tolu, Ismet</creatorcontrib><creatorcontrib>Odabas, Dursun</creatorcontrib><title>Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description><![CDATA[Summary
Aim The aim of this study was to investigate the relationships between bone mineral density (BMD) vs insulin resistance and metabolic risk factors in obese adolescents with nonalcoholic fatty liver disease (NAFLD).
Patients and methods Eighty‐two obese adolescents [45 girls and 37 boys, mean age: 12·3 ± 1·7 years, mean body mass index‐standard deviation score (BMI‐SDS): 1·9 ± 0·2] and 30 control subjects (15 girls and 15 boys, mean age: 12·3 ± 1·45 years, mean BMI‐SDS: 0·5 ± 0·7) were enrolled the study. The obese subjects were divided into two groups based on the presence or absence of liver steatosis with high transaminases (NAFLD group and non‐NAFLD group). Insulin resistance was evaluated by homeostasis model assessment (HOMA‐IR) from fasting samples. BMD was determined by dual‐energy X‐ray absorptiometry.
Results Fasting insulin levels in the NAFLD group were significantly higher than in the non‐NAFLD obese (32·3 ± 24·0 vs 11·02 ± 2·95 mU/l, P < 0·001) and control groups (8·4 ± 2·4 mU/l, P< 0·001). The NAFLD group had higher values of HOMA‐IR than the non‐NAFLD obese (7·3 ± 0·1 vs 2·3 ± 0·7, P < 0·001) and control groups (1·8 ± 0·5, P < 0·001). BMD‐SDS measurements were lower in the NAFLD group than in the non‐NAFLD (0·56 ± 0·3 vs 1·02 ± 0·9, P < 0·001) and control groups (0·56 ± 0·3 vs 1·37 ± 1·04, P < 0·001). BMD‐SDS was positively correlated with BMI‐SDS (r = 0·530, P = 0·004) and negatively correlated with HOMA‐IR (r = −0·628, P = 0·017) in the NAFLD obese group.
Conclusion This study reports the association between BMD‐SDS and insulin resistance in obese adolescents both with and without NAFLD, although the NAFLD group had a lower BMD‐SDS than the non‐NAFLD group. We suggest that NAFLD has a detrimental effect on bone health in adolescents, and it is correlated with increased insulin resistance.]]></description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Bone Density</subject><subject>Calcification, Physiologic</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Endocrinopathies</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - physiopathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Risk Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp90kuP0zAQAOAIgdiy8BeQJYTgkjB2_EgPHFZlWZBWywW0EhfLTiZaF9de4qTb_nscWorEAV9sab7xa6YoCIWK5vFuXdFaipIxKSoGlFbAoW6q3aNicQo8LhZQA5QgJT8rnqW0BgDRgHpanDEqGK1BLYrtKg4DejO6GEjsiQtp8i6QhCG50W3duCcPbrwjNgYkGxdwMJ6k0YxTyphEiwmJ6aLH1GIY00GHGIxv4130riW9GfMu3m1xIJ1LaBI-L570xid8cZzPi28fL7-uPpXXX64-ry6uy5bzpilly0B2KJYMTbdEhrYXbQtge2XAAnBlbV3TXhjJO66Y7a1SoCyIVnEjWX1evDnsez_EnxOmUW9cvqf3JmCckm6UyOdQxbN8-19JgaplxgwyffUPXcdpyA_OSnDRNI2UNKuXRzXZDXb6fnAbM-z1n7_P4PURmNQa3w8mtC79dbwGyYTM7v3BPTiP-1Ocgp57Qa_1XHI9l1zPvaB_94Le6dXlzbzK-eUh36URd6d8M_zQUtVK6NubKy0-MN4sb79rqH8BB9C24A</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Pirgon, Ozgur</creator><creator>Bilgin, Huseyin</creator><creator>Tolu, Ismet</creator><creator>Odabas, Dursun</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease</title><author>Pirgon, Ozgur ; Bilgin, Huseyin ; Tolu, Ismet ; Odabas, Dursun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4488-6c206de592ead9e2ebf5cc00bf7a0b0047bb331f5a64d472bfb7707b05c74a623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Bone Density</topic><topic>Calcification, Physiologic</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Endocrinopathies</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - physiopathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Non-alcoholic Fatty Liver Disease</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Risk Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pirgon, Ozgur</creatorcontrib><creatorcontrib>Bilgin, Huseyin</creatorcontrib><creatorcontrib>Tolu, Ismet</creatorcontrib><creatorcontrib>Odabas, Dursun</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pirgon, Ozgur</au><au>Bilgin, Huseyin</au><au>Tolu, Ismet</au><au>Odabas, Dursun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2011-08</date><risdate>2011</risdate><volume>75</volume><issue>2</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract><![CDATA[Summary
Aim The aim of this study was to investigate the relationships between bone mineral density (BMD) vs insulin resistance and metabolic risk factors in obese adolescents with nonalcoholic fatty liver disease (NAFLD).
Patients and methods Eighty‐two obese adolescents [45 girls and 37 boys, mean age: 12·3 ± 1·7 years, mean body mass index‐standard deviation score (BMI‐SDS): 1·9 ± 0·2] and 30 control subjects (15 girls and 15 boys, mean age: 12·3 ± 1·45 years, mean BMI‐SDS: 0·5 ± 0·7) were enrolled the study. The obese subjects were divided into two groups based on the presence or absence of liver steatosis with high transaminases (NAFLD group and non‐NAFLD group). Insulin resistance was evaluated by homeostasis model assessment (HOMA‐IR) from fasting samples. BMD was determined by dual‐energy X‐ray absorptiometry.
Results Fasting insulin levels in the NAFLD group were significantly higher than in the non‐NAFLD obese (32·3 ± 24·0 vs 11·02 ± 2·95 mU/l, P < 0·001) and control groups (8·4 ± 2·4 mU/l, P< 0·001). The NAFLD group had higher values of HOMA‐IR than the non‐NAFLD obese (7·3 ± 0·1 vs 2·3 ± 0·7, P < 0·001) and control groups (1·8 ± 0·5, P < 0·001). BMD‐SDS measurements were lower in the NAFLD group than in the non‐NAFLD (0·56 ± 0·3 vs 1·02 ± 0·9, P < 0·001) and control groups (0·56 ± 0·3 vs 1·37 ± 1·04, P < 0·001). BMD‐SDS was positively correlated with BMI‐SDS (r = 0·530, P = 0·004) and negatively correlated with HOMA‐IR (r = −0·628, P = 0·017) in the NAFLD obese group.
Conclusion This study reports the association between BMD‐SDS and insulin resistance in obese adolescents both with and without NAFLD, although the NAFLD group had a lower BMD‐SDS than the non‐NAFLD group. We suggest that NAFLD has a detrimental effect on bone health in adolescents, and it is correlated with increased insulin resistance.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21521307</pmid><doi>10.1111/j.1365-2265.2011.04038.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Bone Density Calcification, Physiologic Case-Control Studies Child Endocrinopathies Fatty Liver - complications Fatty Liver - physiopathology Female Fundamental and applied biological sciences. Psychology Humans Insulin Resistance Male Medical sciences Metabolic diseases Non-alcoholic Fatty Liver Disease Obesity Obesity - complications Obesity - physiopathology Risk Factors Vertebrates: endocrinology |
| title | Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease |
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