Circulating miR-210 Predicts Survival in Critically Ill Patients with Acute Kidney Injury

MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable form. We tested whether circulating miRNAs in the plasma of critically ill patients with acute kidney injury (AKI) at the inception of renal replacement therapy are dere...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2011-07, Vol.6 (7), p.1540-1546
Main Authors: Lorenzen, Johan M, Kielstein, Jan T, Hafer, Carsten, Gupta, Shashi K, Kümpers, Philipp, Faulhaber-Walter, Robert, Haller, Hermann, Fliser, Danilo, Thum, Thomas
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute Kidney Injury - genetics
Acute Kidney Injury - mortality
Acute Kidney Injury - therapy
Adult
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Critical Illness
Female
Genetic Markers
Germany
Humans
Kaplan-Meier Estimate
Male
MicroRNAs - blood
Middle Aged
Polymerase Chain Reaction
Proportional Hazards Models
Renal Replacement Therapy
Risk Assessment
Risk Factors
Survival Rate
Time Factors
Treatment Outcome
Up-Regulation
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Summary:MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable form. We tested whether circulating miRNAs in the plasma of critically ill patients with acute kidney injury (AKI) at the inception of renal replacement therapy are deregulated and may predict survival. We profiled miRNAs using RNA isolated from the plasma of patients with AKI and healthy controls. The results were validated in 77 patients with acute kidney injury, 30 age-matched healthy controls, and 18 critically ill patients with acute myocardial infarction by quantitative real-time PCR. Circulating levels of miR-16 and miR-320 were downregulated in the plasma of kidney injury AKI patients, whereas miR-210 was upregulated compared with healthy controls (all P < 0.0001) and disease controls (miR-210 and miR-16: P < 0.0001; miR-320: P = 0.03). Cox regression (P < 0.05) and Kaplan-Meier curve analysis (P = 0.03) revealed miR-210 as an independent and powerful predictor of 28-day survival. Circulating miRNAs are altered in patients with kidney injury AKI. MiR-210 predicts mortality in this patient cohort and may serve as a novel biomarker AKI reflecting pathophysiological changes on a cellular level.
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.00430111