Effect of sublingual misoprostol versus intravenous oxytocin on reducing blood loss at cesarean section in Nigeria: A randomized controlled trial

Aims:  The aim of this study was to compare the effectiveness and safety of sublingual misoprostol with i.v. oxytocin infusion administered after delivery in reducing blood loss at cesarean section in Nigeria. Materials and Methods:  One hundred women with term singleton pregnancy undergoing electiv...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2011-07, Vol.37 (7), p.715-721
Main Authors: Owonikoko, Kola M., Arowojolu, Ayodele O., Okunlola, Michael A.
Format: Article
Language:English
Subjects:
Administration, Sublingual
Adult
blood loss at cesarean section
Blood Loss, Surgical - prevention & control
Cesarean Section - adverse effects
Double-Blind Method
Female
Humans
Infusions, Intravenous
Misoprostol - administration & dosage
Misoprostol - adverse effects
Misoprostol - therapeutic use
Nigeria
Oxytocics - administration & dosage
Oxytocics - adverse effects
Oxytocics - therapeutic use
oxytocin
Oxytocin - administration & dosage
Oxytocin - adverse effects
Oxytocin - therapeutic use
Pregnancy
sublingual misoprostol
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Summary:Aims:  The aim of this study was to compare the effectiveness and safety of sublingual misoprostol with i.v. oxytocin infusion administered after delivery in reducing blood loss at cesarean section in Nigeria. Materials and Methods:  One hundred women with term singleton pregnancy undergoing elective or emergency cesarean section under spinal anesthesia in Nigeria were randomly allocated to receive either misoprostol 400 µg sublingually or i.v. infusion of 20 units oxytocin soon after delivery of the baby. Estimated blood loss at surgery and within the first 4 h post‐operation were measured in both groups. Results:  No significant difference was found in mean blood loss between the oxytocin and misoprostol groups. Similarly, no significant difference occurred between preoperative and postoperative hematocrit levels in both groups. The need for additional oxytocin was similar in both groups. There was significantly less blood loss in the first 4 h after surgery in the misoprostol group than in the oxytocin group (58.2 ± 20.7 vs 80.5 ± 26.8; P‐value = 0.02). The incidence of adverse effects like shivering/pyrexia was significantly higher in the misoprostol group than in the oxytocin group (27/50 vs 1/50, P 
ISSN:1341-8076
1447-0756
DOI:10.1111/j.1447-0756.2010.01399.x