Circulating 20S Proteasome in Patients with Non-metastasized Breast Cancer

Recent data suggest a role of the ubiquitin-proteasome system in various malignancies. In patients with neoplasms, increased extracellular concentrations of circulating 20S proteasome (c-proteasome) have been detected in blood plasma. We tested the hypothesis that the plasma c-proteasome concentrati...

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Bibliographic Details
Published in:Anticancer research 2011-06, Vol.31 (6), p.2197-2201
Main Authors: HOFFMANN, Oliver, HEUBNER, Martin, ANLASIK, Timur, WINTERHALTER, Michael, DAHLMANN, Burkhardt, KASIMIR-BAUER, Sabine, KIMMIG, Rainer, WOHLSCHLAEGER, Jeremias, URS SIXT, Stephan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast Neoplasms - enzymology
Breast Neoplasms - pathology
Female
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Mammary gland diseases
Medical sciences
Middle Aged
Proteasome Endopeptidase Complex - blood
Tumors
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Summary:Recent data suggest a role of the ubiquitin-proteasome system in various malignancies. In patients with neoplasms, increased extracellular concentrations of circulating 20S proteasome (c-proteasome) have been detected in blood plasma. We tested the hypothesis that the plasma c-proteasome concentration is a biomarker associated with tumor stage and nodal status in patients with the primary diagnosis of non-metastatic breast cancer. Venous plasma concentration of 20S proteasome was measured by ELISA technique in 224 non-metastatic breast cancer patients and in 50 healthy volunteers. To assess the relation of proteasome expression to c-proteasome concentration, tumor specimens from 32 patients were immunohistochemically stained for 20S proteasome using an antibody directed against the core subunits of the catalytic domain of the 20S proteasome. The median c-proteasome concentration was higher (p
ISSN:0250-7005
1791-7530