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Biocompatible Micelles Based on Comb-like PEG Derivates: Formation, Characterization, and Photo-responsiveness

A novel comb‐like derivative CPEG‐g‐DNQ was prepared by incorporating light responsive 2‐diazo‐1,2‐naphthoquinone (DNQ) groups into the structure of comb‐like poly(ethylene glycol) (CPEG). DLS and TEM results showed that CPEG‐g‐DNQ self‐assembled into spherical micelles with an average size of about...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2011-07, Vol.32 (14), p.1077-1081
Main Authors: Chen, Chao-Jian, Liu, Gong-Yan, Shi, Ye-Ting, Zhu, Cong-Shan, Pang, Shao-Peng, Liu, Xiang-Sheng, Ji, Jian
Format: Article
Language:English
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Summary:A novel comb‐like derivative CPEG‐g‐DNQ was prepared by incorporating light responsive 2‐diazo‐1,2‐naphthoquinone (DNQ) groups into the structure of comb‐like poly(ethylene glycol) (CPEG). DLS and TEM results showed that CPEG‐g‐DNQ self‐assembled into spherical micelles with an average size of about 135 nm in water. Upon exposure to light, the micelles could be disrupted because of the conversion of hydrophobic DNQ to hydrophilic 3‐indenecarboylic acid. Additionally, hydrophobic coumarin 102 was successfully loaded into the micelles and photo‐induced ON‐OFF release was demonstrated by fluorescence spectroscopy. MTT assay revealed that the micelles are biocompatible. These photo‐responsive micelles might have great potential for controlled release of hydrophobic drugs. Biocompatible photo‐responsive micelles based on DNQ grafted comb‐like PEG are explored as new approach for triggered release of hydrophobic coumarin 102. Cell viability against two cells indicates that the micelles with PEG shell have excellent biocompatibility. Upon exposure to 365nm UV light, the micelles can be disrupted and exhibit photo‐induced ON‐OFF release.
ISSN:1022-1336
1521-3927
1521-3927
DOI:10.1002/marc.201100196