No evidence of an increased mortality risk associated with low levels of glycated haemoglobin in a non-diabetic UK population

Aims/hypothesis There is debate about increased mortality risk associated with low levels of glycaemia. To address this issue, we examined the shape of the risk relationship between glycated haemoglobin and mortality in a UK population. Methods In 17,196 men and women aged 39–82 years participating...

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Bibliographic Details
Published in:Diabetologia 2011-08, Vol.54 (8), p.2025-2032
Main Authors: Pfister, R., Sharp, S. J., Luben, R., Khaw, K.-T., Wareham, N. J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atherosclerosis
Biological and medical sciences
Cancer
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glycated Hemoglobin A - metabolism
Heart attacks
Hemoglobin
Human Physiology
Humans
Internal Medicine
Laboratories
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Mortality
Nutrition
Predation
Public health
Risk Factors
United Kingdom - epidemiology
Women
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Summary:Aims/hypothesis There is debate about increased mortality risk associated with low levels of glycaemia. To address this issue, we examined the shape of the risk relationship between glycated haemoglobin and mortality in a UK population. Methods In 17,196 men and women aged 39–82 years participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study in Norfolk without known diabetes or cardiovascular disease, we estimated HRs for total and cause-specific mortality comparing categories of glycated haemoglobin (
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-011-2162-0