Deep transcranial magnetic stimulation add-on for treatment of negative symptoms and cognitive deficits of schizophrenia: a feasibility study

Treatment for negative symptoms and cognitive deficits, core elements of schizophrenia, remains inadequate. Stimulation of the prefrontal cortex via transcranial magnetic stimulation (TMS) yields only moderate results, possibly due to limited stimulation depth. Deep-TMS enables deeper and wider stim...

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Bibliographic Details
Published in:The international journal of neuropsychopharmacology 2011-08, Vol.14 (7), p.991-996
Main Authors: Levkovitz, Yechiel, Rabany, Liron, Harel, Eiran Vadim, Zangen, Abraham
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antipsychotic Agents - therapeutic use
Cognition Disorders - complications
Cognition Disorders - psychology
Cognition Disorders - therapy
Combined Modality Therapy - instrumentation
Combined Modality Therapy - methods
Feasibility Studies
Female
Humans
Magnetic fields
Male
Middle Aged
Neuropsychological Tests
Placebo effect
Prefrontal Cortex - physiology
Psychiatric Status Rating Scales
Psychotropic drugs
Schizophrenia
Schizophrenia - complications
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Schizophrenia - therapy
Schizophrenic Psychology
Transcranial Magnetic Stimulation - adverse effects
Transcranial Magnetic Stimulation - instrumentation
Transcranial Magnetic Stimulation - methods
Transcranial Magnetic Stimulation - psychology
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Summary:Treatment for negative symptoms and cognitive deficits, core elements of schizophrenia, remains inadequate. Stimulation of the prefrontal cortex via transcranial magnetic stimulation (TMS) yields only moderate results, possibly due to limited stimulation depth. Deep-TMS enables deeper and wider stimulation than before. This preliminary study is the first to examine deep-TMS as a possible add-on treatment for negative symptoms and cognitive deficits of schizophrenia. The effect of 20 daily deep-TMS sessions (20 Hz, 120% motor threshold) over the prefrontal cortex of 15 patients indicated improvement in cognition and negative symptoms that was maintained at 2-wk post-treatment follow-up.
ISSN:1461-1457
1469-5111
DOI:10.1017/S1461145711000642