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Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production
Abstract Background Delayed wound healing is a significant clinical problem in patients who have had previous irradiation. This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing. Methods The effect of Av was studied in radiation-exposed rats compared wit...
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| Published in: | The American journal of surgery 2011-06, Vol.201 (6), p.809-818 |
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| container_title | The American journal of surgery |
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| creator | Atiba, Ayman, M.V.Sc Nishimura, Mayumi, Ph.D Kakinuma, Shizuko, Ph.D Hiraoka, Takeshi, Ph.D Goryo, Masanobu, Ph.D Shimada, Yoshiya, Ph.D Ueno, Hiroshi, Ph.D Uzuka, Yuji, Ph.D |
| description | Abstract Background Delayed wound healing is a significant clinical problem in patients who have had previous irradiation. This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing. Methods The effect of Av was studied in radiation-exposed rats compared with radiation-only and control rats. Skin wounds were excised on the back of rats after 3 days of local radiation. Wound size was measured on days 0, 3, 6, 9, and 12 after wounding. Wound tissues were examined histologically and the expressions of transforming growth factor β-1 (TGF-β-1) and basic fibroblast growth factor (bFGF) were examined by immunohistochemistry and reverse-transcription polymerase chain reaction. Results Wound contraction was accelerated significantly by Av on days 6 and 12 after wounding. Furthermore, the inflammatory cell infiltration, fibroblast proliferation, collagen deposition, angiogenesis, and the expression levels of TGF-β-1 and bFGF were significantly higher in the radiation plus Av group compared with the radiation-only group. Conclusions These data showed the potential application of Av to improve the acute radiation-delayed wound healing by increasing TGF-β-1 and bFGF production. |
| doi_str_mv | 10.1016/j.amjsurg.2010.06.017 |
| format | article |
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This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing. Methods The effect of Av was studied in radiation-exposed rats compared with radiation-only and control rats. Skin wounds were excised on the back of rats after 3 days of local radiation. Wound size was measured on days 0, 3, 6, 9, and 12 after wounding. Wound tissues were examined histologically and the expressions of transforming growth factor β-1 (TGF-β-1) and basic fibroblast growth factor (bFGF) were examined by immunohistochemistry and reverse-transcription polymerase chain reaction. Results Wound contraction was accelerated significantly by Av on days 6 and 12 after wounding. Furthermore, the inflammatory cell infiltration, fibroblast proliferation, collagen deposition, angiogenesis, and the expression levels of TGF-β-1 and bFGF were significantly higher in the radiation plus Av group compared with the radiation-only group. Conclusions These data showed the potential application of Av to improve the acute radiation-delayed wound healing by increasing TGF-β-1 and bFGF production.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2010.06.017</identifier><identifier>PMID: 21396624</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Administration, Oral ; Aloe ; Aloe vera ; Angiogenesis ; Animals ; Apoptosis ; Biological and medical sciences ; Burns ; Cell cycle ; Collagen ; Contraction ; Data processing ; Diabetes ; Disease Models, Animal ; Extracellular matrix ; FGF ; Fibroblast growth factor 2 ; Fibroblast Growth Factors - biosynthesis ; Fibroblast Growth Factors - drug effects ; Fibroblasts ; Follow-Up Studies ; General aspects ; Growth factors ; Immunohistochemistry ; Infiltration ; Inflammation ; Irradiation ; Medical sciences ; Oral administration ; Phytotherapy - methods ; Plant Preparations - administration & dosage ; Polyethylene ; Polymerase chain reaction ; Radiation ; Radiation Injuries - drug therapy ; Radiation Injuries - pathology ; Radiation therapy ; Radiation wound ; Rats ; Rodents ; Skin ; Skin - pathology ; Skin - radiation effects ; Surgery ; TGF-β ; Tissues ; Transforming Growth Factor beta - biosynthesis ; Transforming Growth Factor beta - drug effects ; Transforming growth factor-b ; Treatment Outcome ; Wound healing ; Wound Healing - drug effects ; Wound Healing - radiation effects</subject><ispartof>The American journal of surgery, 2011-06, Vol.201 (6), p.809-818</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-b8baa559471e9575ad6bf6a2b7683f4d71047f9fb16a75424b1fa868c9a07f973</citedby><cites>FETCH-LOGICAL-c477t-b8baa559471e9575ad6bf6a2b7683f4d71047f9fb16a75424b1fa868c9a07f973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24358379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21396624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atiba, Ayman, M.V.Sc</creatorcontrib><creatorcontrib>Nishimura, Mayumi, Ph.D</creatorcontrib><creatorcontrib>Kakinuma, Shizuko, Ph.D</creatorcontrib><creatorcontrib>Hiraoka, Takeshi, Ph.D</creatorcontrib><creatorcontrib>Goryo, Masanobu, Ph.D</creatorcontrib><creatorcontrib>Shimada, Yoshiya, Ph.D</creatorcontrib><creatorcontrib>Ueno, Hiroshi, Ph.D</creatorcontrib><creatorcontrib>Uzuka, Yuji, Ph.D</creatorcontrib><title>Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Delayed wound healing is a significant clinical problem in patients who have had previous irradiation. This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing. Methods The effect of Av was studied in radiation-exposed rats compared with radiation-only and control rats. Skin wounds were excised on the back of rats after 3 days of local radiation. Wound size was measured on days 0, 3, 6, 9, and 12 after wounding. Wound tissues were examined histologically and the expressions of transforming growth factor β-1 (TGF-β-1) and basic fibroblast growth factor (bFGF) were examined by immunohistochemistry and reverse-transcription polymerase chain reaction. Results Wound contraction was accelerated significantly by Av on days 6 and 12 after wounding. Furthermore, the inflammatory cell infiltration, fibroblast proliferation, collagen deposition, angiogenesis, and the expression levels of TGF-β-1 and bFGF were significantly higher in the radiation plus Av group compared with the radiation-only group. Conclusions These data showed the potential application of Av to improve the acute radiation-delayed wound healing by increasing TGF-β-1 and bFGF production.</description><subject>Acute Disease</subject><subject>Administration, Oral</subject><subject>Aloe</subject><subject>Aloe vera</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Burns</subject><subject>Cell cycle</subject><subject>Collagen</subject><subject>Contraction</subject><subject>Data processing</subject><subject>Diabetes</subject><subject>Disease Models, Animal</subject><subject>Extracellular matrix</subject><subject>FGF</subject><subject>Fibroblast growth factor 2</subject><subject>Fibroblast Growth Factors - biosynthesis</subject><subject>Fibroblast Growth Factors - drug effects</subject><subject>Fibroblasts</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Growth factors</subject><subject>Immunohistochemistry</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Irradiation</subject><subject>Medical sciences</subject><subject>Oral administration</subject><subject>Phytotherapy - methods</subject><subject>Plant Preparations - administration & dosage</subject><subject>Polyethylene</subject><subject>Polymerase chain reaction</subject><subject>Radiation</subject><subject>Radiation Injuries - drug therapy</subject><subject>Radiation Injuries - pathology</subject><subject>Radiation therapy</subject><subject>Radiation wound</subject><subject>Rats</subject><subject>Rodents</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>Skin - radiation effects</subject><subject>Surgery</subject><subject>TGF-β</subject><subject>Tissues</subject><subject>Transforming Growth Factor beta - biosynthesis</subject><subject>Transforming Growth Factor beta - drug effects</subject><subject>Transforming growth factor-b</subject><subject>Treatment Outcome</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wound Healing - radiation effects</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFks1u1DAQxyMEotvCI4AsIdRTFjuJP3Khqiq-pEocgLM1sZ2tlyQuttNq34cn4EF4JibsQkUvnOyZ-c2H5--ieMbomlEmXm3XMG7THDfriqKPijVl8kGxYkq2JVOqflisKKVV2QpGj4rjlLZoMtbUj4ujitWtEFWzKr6fD8GRGxeBhAgDATv6yaccIfswETDGDRjMLuF9zo5EsP53rLRugJ2z5DbMkyVXDgY_bUi3Iyn7cR4QQhMLTakPcVyMTQy3-Yr0YHKI5c8fBDCx910M3QAp_xsn1zHY2SytnhSPehiSe3o4T4ovb998vnhfXn589-Hi_LI0jZS57FQHwHnbSOZaLjlY0fUCqk4KVfeNlYw2sm_7jgmQvKmajvWghDItUPTL-qQ43dfF1t9ml7IefcIFDDC5MCetpGCKN4oj-eIeuQ1znHA4zdqKs5ZxppDie8rEkFJ0vb6OfoS404zqRUW91QcV9aKipkKjipj3_FB97kZn_2b9kQ2BlwcAkoGhxyUbn-64puaqli1yZ3vO4dZuvIs6Ge8m46yPzmRtg__vKK_vVTAos8emX93OpbtX61Rpqj8tX275cQwvguEgvwD7YNc5</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Atiba, Ayman, M.V.Sc</creator><creator>Nishimura, Mayumi, Ph.D</creator><creator>Kakinuma, Shizuko, Ph.D</creator><creator>Hiraoka, Takeshi, Ph.D</creator><creator>Goryo, Masanobu, Ph.D</creator><creator>Shimada, Yoshiya, Ph.D</creator><creator>Ueno, Hiroshi, Ph.D</creator><creator>Uzuka, Yuji, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production</title><author>Atiba, Ayman, M.V.Sc ; Nishimura, Mayumi, Ph.D ; Kakinuma, Shizuko, Ph.D ; Hiraoka, Takeshi, Ph.D ; Goryo, Masanobu, Ph.D ; Shimada, Yoshiya, Ph.D ; Ueno, Hiroshi, Ph.D ; Uzuka, Yuji, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-b8baa559471e9575ad6bf6a2b7683f4d71047f9fb16a75424b1fa868c9a07f973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Disease</topic><topic>Administration, Oral</topic><topic>Aloe</topic><topic>Aloe vera</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Burns</topic><topic>Cell cycle</topic><topic>Collagen</topic><topic>Contraction</topic><topic>Data processing</topic><topic>Diabetes</topic><topic>Disease Models, Animal</topic><topic>Extracellular matrix</topic><topic>FGF</topic><topic>Fibroblast growth factor 2</topic><topic>Fibroblast Growth Factors - biosynthesis</topic><topic>Fibroblast Growth Factors - drug effects</topic><topic>Fibroblasts</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Growth factors</topic><topic>Immunohistochemistry</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Irradiation</topic><topic>Medical sciences</topic><topic>Oral administration</topic><topic>Phytotherapy - methods</topic><topic>Plant Preparations - administration & dosage</topic><topic>Polyethylene</topic><topic>Polymerase chain reaction</topic><topic>Radiation</topic><topic>Radiation Injuries - drug therapy</topic><topic>Radiation Injuries - pathology</topic><topic>Radiation therapy</topic><topic>Radiation wound</topic><topic>Rats</topic><topic>Rodents</topic><topic>Skin</topic><topic>Skin - pathology</topic><topic>Skin - radiation effects</topic><topic>Surgery</topic><topic>TGF-β</topic><topic>Tissues</topic><topic>Transforming Growth Factor beta - biosynthesis</topic><topic>Transforming Growth Factor beta - drug effects</topic><topic>Transforming growth factor-b</topic><topic>Treatment Outcome</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wound Healing - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atiba, Ayman, M.V.Sc</creatorcontrib><creatorcontrib>Nishimura, Mayumi, Ph.D</creatorcontrib><creatorcontrib>Kakinuma, Shizuko, Ph.D</creatorcontrib><creatorcontrib>Hiraoka, Takeshi, Ph.D</creatorcontrib><creatorcontrib>Goryo, Masanobu, Ph.D</creatorcontrib><creatorcontrib>Shimada, Yoshiya, Ph.D</creatorcontrib><creatorcontrib>Ueno, Hiroshi, Ph.D</creatorcontrib><creatorcontrib>Uzuka, Yuji, Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atiba, Ayman, M.V.Sc</au><au>Nishimura, Mayumi, Ph.D</au><au>Kakinuma, Shizuko, Ph.D</au><au>Hiraoka, Takeshi, Ph.D</au><au>Goryo, Masanobu, Ph.D</au><au>Shimada, Yoshiya, Ph.D</au><au>Ueno, Hiroshi, Ph.D</au><au>Uzuka, Yuji, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>201</volume><issue>6</issue><spage>809</spage><epage>818</epage><pages>809-818</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Abstract Background Delayed wound healing is a significant clinical problem in patients who have had previous irradiation. This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing. Methods The effect of Av was studied in radiation-exposed rats compared with radiation-only and control rats. Skin wounds were excised on the back of rats after 3 days of local radiation. Wound size was measured on days 0, 3, 6, 9, and 12 after wounding. Wound tissues were examined histologically and the expressions of transforming growth factor β-1 (TGF-β-1) and basic fibroblast growth factor (bFGF) were examined by immunohistochemistry and reverse-transcription polymerase chain reaction. Results Wound contraction was accelerated significantly by Av on days 6 and 12 after wounding. Furthermore, the inflammatory cell infiltration, fibroblast proliferation, collagen deposition, angiogenesis, and the expression levels of TGF-β-1 and bFGF were significantly higher in the radiation plus Av group compared with the radiation-only group. Conclusions These data showed the potential application of Av to improve the acute radiation-delayed wound healing by increasing TGF-β-1 and bFGF production.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21396624</pmid><doi>10.1016/j.amjsurg.2010.06.017</doi><tpages>10</tpages></addata></record> |
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| subjects | Acute Disease Administration, Oral Aloe Aloe vera Angiogenesis Animals Apoptosis Biological and medical sciences Burns Cell cycle Collagen Contraction Data processing Diabetes Disease Models, Animal Extracellular matrix FGF Fibroblast growth factor 2 Fibroblast Growth Factors - biosynthesis Fibroblast Growth Factors - drug effects Fibroblasts Follow-Up Studies General aspects Growth factors Immunohistochemistry Infiltration Inflammation Irradiation Medical sciences Oral administration Phytotherapy - methods Plant Preparations - administration & dosage Polyethylene Polymerase chain reaction Radiation Radiation Injuries - drug therapy Radiation Injuries - pathology Radiation therapy Radiation wound Rats Rodents Skin Skin - pathology Skin - radiation effects Surgery TGF-β Tissues Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - drug effects Transforming growth factor-b Treatment Outcome Wound healing Wound Healing - drug effects Wound Healing - radiation effects |
| title | Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production |
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