Antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata in streptozotocin-induced diabetic rats

The antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata were investigated in streptozotocin (STZ)-induced diabetic rats. The antihyperglycaemic activity was assessed by the reduction in fasting blood glucose (54% at 4th week) and the peak of blood glucose...

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Published in:Natural product research 2011-07, Vol.25 (12), p.1171-1179
Main Authors: Abdel-Sattar, Essam, Harraz, Fathalla M., Ghareib, Salah A., Elberry, Ahmed A., Gabr, Salah, Suliaman, Mansour I.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
antihyperglycaemic
Apocynaceae - chemistry
Asclepiadaceae
Blood Glucose - analysis
Caralluma tuberculata
Cholesterol - blood
Diabetes Mellitus, Experimental - drug therapy
Glucose Tolerance Test
Hypoglycemic Agents - analysis
Hypoglycemic Agents - pharmacology
hypolipidaemic
Hypolipidemic Agents - analysis
Hypolipidemic Agents - pharmacology
Insulin - blood
Methanol
OGTT
Phytotherapy - methods
Plant Extracts - analysis
Plant Extracts - pharmacology
Rats
Triglycerides - blood
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Summary:The antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata were investigated in streptozotocin (STZ)-induced diabetic rats. The antihyperglycaemic activity was assessed by the reduction in fasting blood glucose (54% at 4th week) and the peak of blood glucose at 120 min of an oral glucose tolerance test in diabetic rats. Further, the tested extract also increased plasma insulin by 206.8%. The hypolipidaemic action of the extract was evident by the significant decrease in the levels of total cholesterol, triglycerides and LDL-cholesterol by 41.5%, 36.7% and 49.1%, respectively, compared to diabetic rat values. Interestingly, the extract increased the cardio-protective lipid HDL-cholesterol by 147.97% as compared to diabetic rat value. The present data suggests that the methanolic extract of C. tuberculata has both antihyperglycaemic and hypolipidaemic effects in STZ-induced diabetic rats that may need further studies to be used in the management of diabetes and associated hyperlipedaemia.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2010.490782