Recent Advances in Retromer Biology

The endosomal network is an organized array of intracellular, membranous compartments that function as sorting sites for endosomal and biosynthetic cargo. The fate of endocytic cargo is reliant upon interactions with a number of molecularly distinct sorting complexes, which tightly control the relat...

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Bibliographic Details
Published in:Traffic (Copenhagen, Denmark) Denmark), 2011-08, Vol.12 (8), p.963-971
Main Authors: McGough, Ian J., Cullen, Peter J.
Format: Article
Language:English
Subjects:
Carrier Proteins - metabolism
clathrin
Clathrin - metabolism
cytoskeleton
Cytoskeleton - metabolism
Endosomal Sorting Complexes Required for Transport - metabolism
Endosomes - metabolism
Protein Transport - physiology
retromer
sorting nexin
Sorting Nexins - metabolism
trans-Golgi Network - metabolism
WASH
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Summary:The endosomal network is an organized array of intracellular, membranous compartments that function as sorting sites for endosomal and biosynthetic cargo. The fate of endocytic cargo is reliant upon interactions with a number of molecularly distinct sorting complexes, which tightly control the relationship between sorting of their respective cargo and the physical process of membrane re‐scuplturing required for the formation of transport carries. One such complex, retromer, mediates retrograde transport from endosomes to the trans‐Golgi network (TGN). Disregulation of retromer has been implicated in a host of disease states including late‐onset Alzheimer's. Rather than give a broad overview of retromer biology, here we aim to outline the recent advances in understanding this complex, focussing on the involvement of both clathrin and the cytoskeleton in retromer function.
ISSN:1398-9219
1600-0854
DOI:10.1111/j.1600-0854.2011.01201.x