‘Personalised medicine’ through ‘personalised medicines’: Time to integrate advanced, non-invasive imaging approaches and smart drug delivery systems

In this Commentary, the authors briefly discuss the status of efforts to individualize therapeutic interventions. They differentiate between the widely discussed idea of further shaping ‘personalized medicine’ approaches by using (new) biomarkers and (molecular) imaging techniques and the much less...

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Bibliographic Details
Published in:International journal of pharmaceutics 2011-08, Vol.415 (1), p.5-8
Main Authors: Crommelin, Daan J.A., Storm, Gert, Luijten, Peter
Format: Article
Language:English
Subjects:
Biomarkers
Drug delivery
drug delivery systems
Drug Delivery Systems - economics
Drug Delivery Systems - methods
Drug Delivery Systems - trends
drugs
High intensity focused ultrasonic radiation
Humans
image analysis
Individualized medicine
Liposomes
Magnetic Resonance Imaging
medicine
Molecular Imaging
patients
Precision Medicine - economics
Precision Medicine - methods
Precision Medicine - trends
Radiation
Therapeutic applications
Ultrasonics
Ultrasonography
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Summary:In this Commentary, the authors briefly discuss the status of efforts to individualize therapeutic interventions. They differentiate between the widely discussed idea of further shaping ‘personalized medicine’ approaches by using (new) biomarkers and (molecular) imaging techniques and the much less debated topic of ‘personalized medicines’: medicines, often carrier based, specifically geared to treat the individual patient optimally. An example where ‘personalized medicine’ is achieved by ‘personalized medicines’ is described: a smart drug delivery system is activated at the target site by non-invasive radiation (focused ultrasonic radiation, FU) while this spatial and temporal release process is guided and monitored by MRI (Magnetic Resonance Imaging guided High Intensity Focused Ultrasonic, MRIgHIFU).
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.02.010