Survey of Aspirin Use in Sturge-Weber Syndrome

Sturge-Weber syndrome is a rare congenital disorder. Seizures, stroke-like episodes, glaucoma, headache, and developmental delay are frequently associated features. An Internet-based questionnaire was designed to assess the frequency of use, effectiveness, and safety of aspirin treatment in Sturge-W...

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Bibliographic Details
Published in:Journal of child neurology 2011-06, Vol.26 (6), p.692-702
Main Authors: Bay, Mihee J., Kossoff, Eric H., Lehmann, Christoph U., Zabel, T. Andrew, Comi, Anne M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aspirin - therapeutic use
Child
Child, Preschool
Female
Fibrinolytic Agents - therapeutic use
Health Surveys
Humans
Infant
Male
Middle Aged
Sturge-Weber Syndrome - diagnosis
Sturge-Weber Syndrome - drug therapy
Sturge-Weber Syndrome - epidemiology
Sturge-Weber Syndrome - rehabilitation
Surveys and Questionnaires
Young Adult
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Summary:Sturge-Weber syndrome is a rare congenital disorder. Seizures, stroke-like episodes, glaucoma, headache, and developmental delay are frequently associated features. An Internet-based questionnaire was designed to assess the frequency of use, effectiveness, and safety of aspirin treatment in Sturge-Weber syndrome. Thirty-four of 98 subjects who completed the survey reported having used aspirin. The mean number of reported stroke-like episodes was reduced from 1.1 to 0.3 per month in the year after starting aspirin (n = 26, p = .014). The median number of seizures was significantly reduced from 3 to 1 episodes per month (n = 21, p = .002). Thirty-nine percent of subjects reported a history of complications (predominantly increased bruising or gum/nose bleeding) while on aspirin; however, none reported discontinuing aspirin because of side effects. Our study showed a significant relative reduction in both self-reported seizure frequency and stroke-like episodes after starting aspirin. It also suggests that low-dose aspirin can be safely used in these patients.
ISSN:0883-0738
1708-8283
DOI:10.1177/0883073810388646