Biological monitoring of exposure to di(2-ethylhexyl) phthalate in six French factories: a field study

Objective The aim of this study was to assess, by biological monitoring, workers’ exposure to di(2-ethylhexyl) phthalate (DEHP) in the flexible-PVC industry in France to provide additional occupational exposure data, which are particularly scarce. Method Over 5 days of pre-and post-shift sampling, t...

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Bibliographic Details
Published in:International archives of occupational and environmental health 2011-06, Vol.84 (5), p.523-531
Main Authors: Gaudin, R., Marsan, P., Ndaw, S., Robert, A., Ducos, P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biology
Biomonitoring
Caproates - urine
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Industry
Diethylhexyl Phthalate - analogs & derivatives
Diethylhexyl Phthalate - urine
Earth and Environmental Science
Environment
Environmental Health
Environmental monitoring
Environmental Monitoring - methods
Factories
Female
France
Humans
Liquid chromatography
Male
Mass spectrometry
Medical sciences
Metabolites
Occupational exposure
Occupational Exposure - analysis
Occupational Exposure - prevention & control
Occupational Medicine/Industrial Medicine
Original Article
Phthalates
Phthalic Acids - urine
Plasticizers - analysis
Rehabilitation
Risk assessment
Toxicology
Various organic compounds
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Summary:Objective The aim of this study was to assess, by biological monitoring, workers’ exposure to di(2-ethylhexyl) phthalate (DEHP) in the flexible-PVC industry in France to provide additional occupational exposure data, which are particularly scarce. Method Over 5 days of pre-and post-shift sampling, three urinary metabolites of DEHP, mono (2-ethylhexyl) phthalate (MEHP), mono (5-carboxy-2-ethylpentyl) phthalate (5cx-MEPP) and 2-ethylhexanoic acid (2-EHA) were quantified in 62 workers and 29 controls from six factories. Analyses were performed by high-performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) after on-line extraction. Results Median concentrations of the pre- and post-shift urinary samples in the exposed workers were 12.6 and 28.7 μg/l for MEHP, 38.6 and 84.4 μg/l for 5cx-MEPP and 20.4 and 70.6 μg/l for 2-EHA, respectively. In the controls, the corresponding values were 4.8 and 4.7 μg/l for MEHP, 15.1 and 12.4 μg/l for 5cx-MEPP and 21.8 and 20.5 μg/l for 2-EHA, respectively. There was a significant increase (Mann–Whitney U -test, P  
ISSN:0340-0131
1432-1246
DOI:10.1007/s00420-010-0566-7