Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk

Background/objective: Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4). Subjects/Methods:...

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Bibliographic Details
Published in:European journal of clinical nutrition 2011-06, Vol.65 (6), p.703-710
Main Authors: Canales, A, Sánchez-Muniz, F J, Bastida, S, Librelotto, J, Nus, M, Corella, D, Guillen, M, Benedi, J
Format: Article
Language:English
Subjects:
631/208/212/2130
631/208/457/649
692/699/75
Adhesion
Apolipoprotein A-I - blood
Apolipoproteins A - blood
Apolipoproteins A - genetics
Aryldialkylphosphatase - blood
Aryldialkylphosphatase - genetics
Biological and medical sciences
Biomarkers
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - genetics
Cardiovascular Diseases - prevention & control
Cell adhesion molecules
Cell Adhesion Molecules - blood
Cholesterol, HDL - blood
Clinical Nutrition
Composition
Control
Coronary heart disease
Diet
Enrichment
Epidemiology
Feeding. Feeding behavior
Female
Food, Fortified
Fundamental and applied biological sciences. Psychology
Gene polymorphism
Genes
Health aspects
Health risks
Heart
Humans
Inflammation
Inflammation Mediators - blood
Intercellular Adhesion Molecule-1 - blood
Internal Medicine
Juglans
Leukotriene B4
Leukotriene B4 - blood
Male
Meat
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Nuts
original-article
Paraoxonase
Plant Preparations - pharmacology
Polymorphism
Polymorphism, Genetic
Precooked meat
Prevention
Public Health
Risk
Risk Factors
Vascular Cell Adhesion Molecule-1 - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Walnut
Walnuts
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Summary:Background/objective: Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4). Subjects/Methods: In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4–6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed. Results: Individuals consuming walnut-enriched meat displayed higher paraoxonase activity ( P
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2011.20