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Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk
Background/objective: Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4). Subjects/Methods:...
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| Published in: | European journal of clinical nutrition 2011-06, Vol.65 (6), p.703-710 |
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| cites | cdi_FETCH-LOGICAL-c606t-bfcb594908451777f2c1376f0d5863669f7770dca910dc31a0e0a9c3fe05a0b13 |
| container_end_page | 710 |
| container_issue | 6 |
| container_start_page | 703 |
| container_title | European journal of clinical nutrition |
| container_volume | 65 |
| creator | Canales, A Sánchez-Muniz, F J Bastida, S Librelotto, J Nus, M Corella, D Guillen, M Benedi, J |
| description | Background/objective:
Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4).
Subjects/Methods:
In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4–6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed.
Results:
Individuals consuming walnut-enriched meat displayed higher paraoxonase activity (
P |
| doi_str_mv | 10.1038/ejcn.2011.20 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_876229475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A258910006</galeid><sourcerecordid>A258910006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c606t-bfcb594908451777f2c1376f0d5863669f7770dca910dc31a0e0a9c3fe05a0b13</originalsourceid><addsrcrecordid>eNqF0ktvEzEQAOAVAtFQuHFGFgi4dMt4H_buMVTlIQXKoXBdOd5x4uB4g-1N1Z_FP8SbhKZFqdBKs_L4G780SfKcwimFvHqHC2lPM6A0hgfJiBacpSUr4GEygros0hyAHyVPvF8AxEmePU6OMloAzwo-Sn6fK4UykE6RK2FsH1K0Tss5tmSJIuYtCXMkDo0IurN-rldkiuEK0ZIfZ-MvJ-TzJgrbksnl-4IYXKPxm_G3i68pJUIGvdbhmmhLxqtuXJCcwe15Y9AgkcI5jS5WhiilQ-HjGWK21d1aeNkb4YjT_ufT5JESxuOz3f84-f7h_PLsUzq5-BjPMkklAxbSqZLTsi5qqIqScs5VJmnOmYK2rFjOWK1iElopahpjTgUgiFrmCqEUMKX5cfJ2u-7Kdb969KFZai_RGGGx631TcZZldcHL_0tW8zrPWR7ly3_kouudjdcYUJExxiGiV_ehjEVTAoVqr2bCYKOt6oITcti4GWdlFW8FwKJKD6gZWnTCdBaVjuk7_vSAj1-LSy0PFry5VTBHYcLcd6bfNMtdeLKF0nXeO1TNyumlcNcNhWZo5GZo5GZo5Bgif7F7hH66xPYG_-3cCF7vQGwOYZQTVmq_dwWtWV7D_gV8nLIzdPvXvGdjsvVWhN7hzYIDGkwkfwDJJw7T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642650108</pqid></control><display><type>article</type><title>Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk</title><source>Electronic Journals Library</source><creator>Canales, A ; Sánchez-Muniz, F J ; Bastida, S ; Librelotto, J ; Nus, M ; Corella, D ; Guillen, M ; Benedi, J</creator><creatorcontrib>Canales, A ; Sánchez-Muniz, F J ; Bastida, S ; Librelotto, J ; Nus, M ; Corella, D ; Guillen, M ; Benedi, J</creatorcontrib><description>Background/objective:
Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4).
Subjects/Methods:
In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4–6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed.
Results:
Individuals consuming walnut-enriched meat displayed higher paraoxonase activity (
P
<0.001), lower levels of sICAM and aVCAM (
P
=0.046,
P
=0.012, respectively) and leukotriene B4 (
P
=0.044), and lower paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios (both,
P
<0.001) than those consuming LM. Paraoxonase levels correlated negatively with those of sICAM (
r
=−0.471,
P
<0.01). Significant decreases (at least
P
<0.05) were observed in sICAM concentrations in PON-1 55LM+MM, PON-1 QQ192 and APOA4-2 carriers while decreases in sVCAM in QR+RR and APOA4-1 carriers were observed. Paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios were significantly influenced by paraoxonase polymorphisms.
Conclusions:
Walnut-enriched meat appears as a functional meat as consumed in the framework of a mix diet lowered the concentration of some selected inflammatory chemoattractant biomarkers. This effect was largely influenced by PON-1 and Apo A4-360 polymorphisms.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2011.20</identifier><identifier>PMID: 21407247</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/212/2130 ; 631/208/457/649 ; 692/699/75 ; Adhesion ; Apolipoprotein A-I - blood ; Apolipoproteins A - blood ; Apolipoproteins A - genetics ; Aryldialkylphosphatase - blood ; Aryldialkylphosphatase - genetics ; Biological and medical sciences ; Biomarkers ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - prevention & control ; Cell adhesion molecules ; Cell Adhesion Molecules - blood ; Cholesterol, HDL - blood ; Clinical Nutrition ; Composition ; Control ; Coronary heart disease ; Diet ; Enrichment ; Epidemiology ; Feeding. Feeding behavior ; Female ; Food, Fortified ; Fundamental and applied biological sciences. Psychology ; Gene polymorphism ; Genes ; Health aspects ; Health risks ; Heart ; Humans ; Inflammation ; Inflammation Mediators - blood ; Intercellular Adhesion Molecule-1 - blood ; Internal Medicine ; Juglans ; Leukotriene B4 ; Leukotriene B4 - blood ; Male ; Meat ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Nuts ; original-article ; Paraoxonase ; Plant Preparations - pharmacology ; Polymorphism ; Polymorphism, Genetic ; Precooked meat ; Prevention ; Public Health ; Risk ; Risk Factors ; Vascular Cell Adhesion Molecule-1 - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Walnut ; Walnuts</subject><ispartof>European journal of clinical nutrition, 2011-06, Vol.65 (6), p.703-710</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2011.</rights><rights>Copyright Nature Publishing Group Jun 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-bfcb594908451777f2c1376f0d5863669f7770dca910dc31a0e0a9c3fe05a0b13</citedby><cites>FETCH-LOGICAL-c606t-bfcb594908451777f2c1376f0d5863669f7770dca910dc31a0e0a9c3fe05a0b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24196390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21407247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canales, A</creatorcontrib><creatorcontrib>Sánchez-Muniz, F J</creatorcontrib><creatorcontrib>Bastida, S</creatorcontrib><creatorcontrib>Librelotto, J</creatorcontrib><creatorcontrib>Nus, M</creatorcontrib><creatorcontrib>Corella, D</creatorcontrib><creatorcontrib>Guillen, M</creatorcontrib><creatorcontrib>Benedi, J</creatorcontrib><title>Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/objective:
Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4).
Subjects/Methods:
In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4–6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed.
Results:
Individuals consuming walnut-enriched meat displayed higher paraoxonase activity (
P
<0.001), lower levels of sICAM and aVCAM (
P
=0.046,
P
=0.012, respectively) and leukotriene B4 (
P
=0.044), and lower paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios (both,
P
<0.001) than those consuming LM. Paraoxonase levels correlated negatively with those of sICAM (
r
=−0.471,
P
<0.01). Significant decreases (at least
P
<0.05) were observed in sICAM concentrations in PON-1 55LM+MM, PON-1 QQ192 and APOA4-2 carriers while decreases in sVCAM in QR+RR and APOA4-1 carriers were observed. Paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios were significantly influenced by paraoxonase polymorphisms.
Conclusions:
Walnut-enriched meat appears as a functional meat as consumed in the framework of a mix diet lowered the concentration of some selected inflammatory chemoattractant biomarkers. This effect was largely influenced by PON-1 and Apo A4-360 polymorphisms.</description><subject>631/208/212/2130</subject><subject>631/208/457/649</subject><subject>692/699/75</subject><subject>Adhesion</subject><subject>Apolipoprotein A-I - blood</subject><subject>Apolipoproteins A - blood</subject><subject>Apolipoproteins A - genetics</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cell adhesion molecules</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Clinical Nutrition</subject><subject>Composition</subject><subject>Control</subject><subject>Coronary heart disease</subject><subject>Diet</subject><subject>Enrichment</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food, Fortified</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heart</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - blood</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Internal Medicine</subject><subject>Juglans</subject><subject>Leukotriene B4</subject><subject>Leukotriene B4 - blood</subject><subject>Male</subject><subject>Meat</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Nuts</subject><subject>original-article</subject><subject>Paraoxonase</subject><subject>Plant Preparations - pharmacology</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Precooked meat</subject><subject>Prevention</subject><subject>Public Health</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Walnut</subject><subject>Walnuts</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqF0ktvEzEQAOAVAtFQuHFGFgi4dMt4H_buMVTlIQXKoXBdOd5x4uB4g-1N1Z_FP8SbhKZFqdBKs_L4G780SfKcwimFvHqHC2lPM6A0hgfJiBacpSUr4GEygros0hyAHyVPvF8AxEmePU6OMloAzwo-Sn6fK4UykE6RK2FsH1K0Tss5tmSJIuYtCXMkDo0IurN-rldkiuEK0ZIfZ-MvJ-TzJgrbksnl-4IYXKPxm_G3i68pJUIGvdbhmmhLxqtuXJCcwe15Y9AgkcI5jS5WhiilQ-HjGWK21d1aeNkb4YjT_ufT5JESxuOz3f84-f7h_PLsUzq5-BjPMkklAxbSqZLTsi5qqIqScs5VJmnOmYK2rFjOWK1iElopahpjTgUgiFrmCqEUMKX5cfJ2u-7Kdb969KFZai_RGGGx631TcZZldcHL_0tW8zrPWR7ly3_kouudjdcYUJExxiGiV_ehjEVTAoVqr2bCYKOt6oITcti4GWdlFW8FwKJKD6gZWnTCdBaVjuk7_vSAj1-LSy0PFry5VTBHYcLcd6bfNMtdeLKF0nXeO1TNyumlcNcNhWZo5GZo5GZo5Bgif7F7hH66xPYG_-3cCF7vQGwOYZQTVmq_dwWtWV7D_gV8nLIzdPvXvGdjsvVWhN7hzYIDGkwkfwDJJw7T</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Canales, A</creator><creator>Sánchez-Muniz, F J</creator><creator>Bastida, S</creator><creator>Librelotto, J</creator><creator>Nus, M</creator><creator>Corella, D</creator><creator>Guillen, M</creator><creator>Benedi, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20110601</creationdate><title>Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk</title><author>Canales, A ; Sánchez-Muniz, F J ; Bastida, S ; Librelotto, J ; Nus, M ; Corella, D ; Guillen, M ; Benedi, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-bfcb594908451777f2c1376f0d5863669f7770dca910dc31a0e0a9c3fe05a0b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/212/2130</topic><topic>631/208/457/649</topic><topic>692/699/75</topic><topic>Adhesion</topic><topic>Apolipoprotein A-I - blood</topic><topic>Apolipoproteins A - blood</topic><topic>Apolipoproteins A - genetics</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Cell adhesion molecules</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Clinical Nutrition</topic><topic>Composition</topic><topic>Control</topic><topic>Coronary heart disease</topic><topic>Diet</topic><topic>Enrichment</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food, Fortified</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Heart</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation Mediators - blood</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Internal Medicine</topic><topic>Juglans</topic><topic>Leukotriene B4</topic><topic>Leukotriene B4 - blood</topic><topic>Male</topic><topic>Meat</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Nuts</topic><topic>original-article</topic><topic>Paraoxonase</topic><topic>Plant Preparations - pharmacology</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Precooked meat</topic><topic>Prevention</topic><topic>Public Health</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Walnut</topic><topic>Walnuts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canales, A</creatorcontrib><creatorcontrib>Sánchez-Muniz, F J</creatorcontrib><creatorcontrib>Bastida, S</creatorcontrib><creatorcontrib>Librelotto, J</creatorcontrib><creatorcontrib>Nus, M</creatorcontrib><creatorcontrib>Corella, D</creatorcontrib><creatorcontrib>Guillen, M</creatorcontrib><creatorcontrib>Benedi, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest_Research Library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canales, A</au><au>Sánchez-Muniz, F J</au><au>Bastida, S</au><au>Librelotto, J</au><au>Nus, M</au><au>Corella, D</au><au>Guillen, M</au><au>Benedi, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>65</volume><issue>6</issue><spage>703</spage><epage>710</epage><pages>703-710</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/objective:
Cardiovascular risk depends largely on paraoxonase (PON-1) and apolipoprotein A4 (APOA4) gene polymorphisms. To compare the effects of consumption of walnut-enriched meat versus low-fat meat (LM) on selected soluble adhesion molecules and leukotrienes (LTB4).
Subjects/Methods:
In all 22 subjects at increased cardiovascular risk were taken. It is a non-blinded, cross-over, placebo-controlled study. Two 5-week experimental periods separated by 4–6 week wash-out interval. Participants consumed walnut-enriched meat during one period and LM during the other. Diet characteristics, HDLc, Apo A1, paraoxonase, sVCAM-1, sICAM-1 and LTB4 were analysed. PON-1 55, PON-1 192 and APOA4 360 polymorphism effects were also assessed.
Results:
Individuals consuming walnut-enriched meat displayed higher paraoxonase activity (
P
<0.001), lower levels of sICAM and aVCAM (
P
=0.046,
P
=0.012, respectively) and leukotriene B4 (
P
=0.044), and lower paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios (both,
P
<0.001) than those consuming LM. Paraoxonase levels correlated negatively with those of sICAM (
r
=−0.471,
P
<0.01). Significant decreases (at least
P
<0.05) were observed in sICAM concentrations in PON-1 55LM+MM, PON-1 QQ192 and APOA4-2 carriers while decreases in sVCAM in QR+RR and APOA4-1 carriers were observed. Paraoxonase-1/HDLc and paraoxonase-1/Apo A1 ratios were significantly influenced by paraoxonase polymorphisms.
Conclusions:
Walnut-enriched meat appears as a functional meat as consumed in the framework of a mix diet lowered the concentration of some selected inflammatory chemoattractant biomarkers. This effect was largely influenced by PON-1 and Apo A4-360 polymorphisms.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21407247</pmid><doi>10.1038/ejcn.2011.20</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2011-06, Vol.65 (6), p.703-710 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_876229475 |
| source | Electronic Journals Library |
| subjects | 631/208/212/2130 631/208/457/649 692/699/75 Adhesion Apolipoprotein A-I - blood Apolipoproteins A - blood Apolipoproteins A - genetics Aryldialkylphosphatase - blood Aryldialkylphosphatase - genetics Biological and medical sciences Biomarkers Cardiology. Vascular system Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Cardiovascular Diseases - prevention & control Cell adhesion molecules Cell Adhesion Molecules - blood Cholesterol, HDL - blood Clinical Nutrition Composition Control Coronary heart disease Diet Enrichment Epidemiology Feeding. Feeding behavior Female Food, Fortified Fundamental and applied biological sciences. Psychology Gene polymorphism Genes Health aspects Health risks Heart Humans Inflammation Inflammation Mediators - blood Intercellular Adhesion Molecule-1 - blood Internal Medicine Juglans Leukotriene B4 Leukotriene B4 - blood Male Meat Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Nuts original-article Paraoxonase Plant Preparations - pharmacology Polymorphism Polymorphism, Genetic Precooked meat Prevention Public Health Risk Risk Factors Vascular Cell Adhesion Molecule-1 - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Walnut Walnuts |
| title | Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T05%3A58%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20walnut-enriched%20meat%20on%20the%20relationship%20between%20VCAM,%20ICAM,%20and%20LTB4%20levels%20and%20PON-1%20activity%20in%20ApoA4%20360%20and%20PON-1%20allele%20carriers%20at%20increased%20cardiovascular%20risk&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Canales,%20A&rft.date=2011-06-01&rft.volume=65&rft.issue=6&rft.spage=703&rft.epage=710&rft.pages=703-710&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2011.20&rft_dat=%3Cgale_proqu%3EA258910006%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c606t-bfcb594908451777f2c1376f0d5863669f7770dca910dc31a0e0a9c3fe05a0b13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2642650108&rft_id=info:pmid/21407247&rft_galeid=A258910006&rfr_iscdi=true |