Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase

• Published in: Bioorganic & medicinal chemistry 2011-06, Vol.19 (11), p.3367-3371
• Main Authors: al-Rashida, Mariya, Ashraf, Muhammad, Hussain, Bushra, Nagra, Saeed Ahmad, Abbas, Ghulam
• Format: Article
• Language: English
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; carbonate dehydratase; Carbonic anhydrase; Carbonic anhydrase inhibitors; Carbonic Anhydrase Inhibitors - chemical synthesis; Carbonic Anhydrase Inhibitors - chemistry; Carbonic Anhydrase Inhibitors - pharmacology; Carbonic Anhydrases - chemistry; Carbonic Anhydrases - metabolism; Cattle; chemistry; Chromones - chemical synthesis; Chromones - chemistry; Chromones - pharmacology; Drug Evaluation, Preclinical; Enzymes and enzyme inhibitors; Formylchromones; Fundamental and applied biological sciences. Psychology; Hydrogen Bonding; inhibitory concentration 50; Lyases; Medical sciences; Miscellaneous; Molecular Conformation; Pharmacology. Drug treatments; Sulfonamides; Sulfonamides - chemistry
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2011.04.040

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC 50 values ranged between 4.31 ± 0.001 and 29.12 ± 0.008 μmol. Compounds derived from 6-fluoro-3-formylchromones were the most active.