Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women

• Published in: International Journal of Obesity 2011-06, Vol.35 (6), p.793-799
• Main Authors: Brinkley, T.E, Wang, X, Kume, N, Mitsuoka, H, Nicklas, B.J
• Format: Article
• Language: English
• Subjects: 631/208/200; 692/699/1702/393; 692/700/459/284; Aerobic exercises; Aged; Biological and medical sciences; blood lipids; Blood pressure; body fat; Body Mass Index; Body weight; body weight changes; Caloric Restriction - methods; Cardiovascular diseases; Development and progression; Dietary restrictions; energy; Epidemiology; Exercise; Exercise Therapy; Female; Health Promotion and Disease Prevention; Humans; Internal Medicine; Intervention; Lipids; low density lipoprotein; Low density lipoproteins; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Obesity; Obesity, Abdominal - blood; Obesity, Abdominal - therapy; original-article; overweight; Overweight - blood; Overweight - therapy; Oxygen consumption; Physical training; Physiological aspects; postmenopause; Postmenopause - blood; Public Health; Receptors, Oxidized LDL - blood; Receptors, Oxidized LDL - genetics; regression analysis; Risk factors; Scavenger Receptors, Class E - blood; Scavenger Receptors, Class E - genetics; waist; weight loss; Weight Loss - genetics; women
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2010.199

Background: Elevated circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) have been observed in obese persons and are reduced by weight loss. However, it is not known whether combining caloric restriction (CR) with exercise training is better in reducing sLOX-1 levels than CR alone. Objective: We examined whether the addition of aerobic exercise to a weight loss intervention differentially affects sLOX-1 levels in 61 abdominally obese post-menopausal women randomly assigned to a CR only (n=22), CR+moderate-intensity exercise (n=22) or CR+vigorous-intensity exercise (n=17) intervention for 20 weeks. The caloric deficit was approximately 2800 kcal per week for all groups. Results: The intervention groups were similar at baseline with respect to body weight, body composition, lipids and blood pressure. However, plasma sLOX-1 levels were higher in the CR-only group (99.90+/-8.23 pg ml-1) compared with both the CR+moderate-intensity exercise (69.39+/-8.23 pg ml-1, P=0.01) and the CR+vigorous-intensity exercise (72.83+/-9.36 pg ml-1, P=0.03) groups. All three interventions significantly reduced body weight (approximately14%), body fat and waist and hip circumferences to a similar degree. These changes were accompanied by a 23% reduction in sLOX-1 levels overall (-19.00+/-30.08 pg ml-1, P