MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study

• Published in: Journal of science and medicine in sport 2010-09, Vol.13 (5), p.526-530
• Main Authors: Cupeiro, Rocío, Benito, Pedro J, Maffulli, Nicola, Calderón, F. Javier, González-Lamuño, Domingo
• Format: Article
• Language: English
• Subjects: A1470T polymorphism; Adult; Circuit training; Circuit weight training; Circuits; Exercise (intensity); Gene polymorphism; Genetics; Genotype; Heterozygotes; Homozygotes; Humans; Influence; Lactate accumulation; Lactic acid; Lactic Acid - metabolism; Male; Measurement; Men; Metabolic disorders; Monocarboxylate transporters; Monocarboxylic Acid Transporters - genetics; Muscles; Mutation; Oxidation; Physical Endurance - genetics; Physical Endurance - physiology; Physical Medicine and Rehabilitation; Physical training; Pilot Projects; Polymorphism, Single Nucleotide; Repetition; Sarcolemma; Sport science; Sports Medicine; Sports training; Symporters - genetics; Weightlifting; Young Adult
• ISSN: 1440-2440; 1878-1861
• DOI: 10.1016/j.jsams.2009.07.004

Abstract Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCT1 variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high intensity circuit training. Ten men aged 20–26 performed three controlled circuit training (CWT) sessions at 60%, 70%, and 80% of the 15 repetition maximum (15 RM), in non-consecutive days. CWT included three sets of a circuit of eight exercises, obtaining lactate measurements immediately after each set had been completed. Two independent variables were analysed: MTC1 genotypes according to the presence or absence of the A1470T polymorphism, and the intensity of circuit training. Genotype distributions were in Hardy–Weinberg equilibrium, being 30% wild-type, 50% heterozygotes, and 20% mutated homozygotes. Mean lactate concentration at 80% of 15 RM were significantly higher than the mean lactate values at the other intensities ( p < 0.01). Significant differences between genetic groups were found in the lactate accumulation slope at 80% of 15 RM ( p = 0.02) and in the maximal lactate concentration reached by all subjects in the study ( Lmax ) ( p = 0.03). The carriers of the A1470T polymorphism in the MTC1 gene seem to exhibit a worse lactate transport capability into the less active muscle cells for oxidation.