Cell microcarriers and microcapsules of stimuli-responsive polymers

Cell microcarriers and microcapsules have presented a wide range of potential applications. This article overviews their role in biotechnology with focus on the progress accomplished using stimuli-responsive polymers. Key properties of cell microcarriers and microcapsules are identified, followed by...

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Bibliographic Details
Published in:Journal of controlled release 2011-02, Vol.149 (3), p.209-224
Main Authors: Brun-Graeppi, Amanda K. Andriola Silva, Richard, Cyrille, Bessodes, Michel, Scherman, Daniel, Merten, Otto-Wilhelm
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biocompatible Materials - pharmacokinetics
Biological and medical sciences
biotechnology
Capsules - chemistry
Capsules - metabolism
Capsules - pharmacokinetics
Cell microcapsules
Cell microcarriers
Characterization techniques
Drug Carriers - chemistry
Drug Carriers - metabolism
Drug Carriers - pharmacokinetics
Drug Compounding - methods
gelation
gels
General pharmacology
Humans
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polymers
Polymers - chemistry
Polymers - metabolism
Polymers - pharmacokinetics
Production methods
Stimuli-responsive polymers
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Summary:Cell microcarriers and microcapsules have presented a wide range of potential applications. This article overviews their role in biotechnology with focus on the progress accomplished using stimuli-responsive polymers. Key properties of cell microcarriers and microcapsules are identified, followed by a description of the chemistry and gel formation mechanism of some of the stimuli-responsive polymers used to design them. Production methods are introduced and characterization techniques for evaluating such microsystems are equally presented. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2010.09.023