Mineral water administration may increase kidney elimination of urea, creatinine and folic acid in a concentration-dependent fashion

In a previous experimental study we showed that the administration of a large water load in a short time increases the urinary flow and the transport capacity in the excretory tract of the rabbit ureter. In human subjects drinking a water load of 25 ml/kg(BW) in 30 minutes, diuresis, creatinine and...

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Bibliographic Details
Published in:International journal of artificial organs 2010-05, Vol.33 (5), p.317-320
Main Authors: CALOMINO, Francesco, DI PAOLO, Nicola, NICOLAI, Giulia, MIGLIO, Antonio
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Creatinine
Creatinine - blood
Diuresis
Drinking
Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition
Folic Acid - blood
Humans
Intensive care medicine
Kidney - metabolism
Magnesium - blood
Medical sciences
Middle Aged
Mineral Waters - administration & dosage
Models, Biological
Time Factors
Urea - blood
Young Adult
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Summary:In a previous experimental study we showed that the administration of a large water load in a short time increases the urinary flow and the transport capacity in the excretory tract of the rabbit ureter. In human subjects drinking a water load of 25 ml/kg(BW) in 30 minutes, diuresis, creatinine and urea clearance increase more than in those drinking the same load in 24 hours. The aim of the present study was to investigate possible correlations between percent reduction and baseline values of serum urea, creatinine, folic acid, and magnesium in humans. 20 volunteers were divided in two groups. Subjects in group 1 received a water load of 25 ml/kg(BW) in 24 hours followed by the same load in 30 minutes. Subjects in group 2 received the same water load but in inverse order. Before and after each water administration, the following variables were measured and compared: diuresis, serum urea, creatinine, folic acid and magnesium concentration, and urea and creatinine clearance. Serum urea and folic acid concentration decreased up to 40% after administration of the water load in 24 hours. Serum creatinine concentration decreased up to 20% after administration of the water load in 30 minutes. The concentration drop of these metabolites increased with increasing baseline metabolite concentrations.
ISSN:0391-3988
1724-6040
DOI:10.1177/039139881003300508