Brain nicotinic acetylcholine receptor occupancy: Effect of secondhand smoke exposure

Based on this observation we hypothesized that SHS exposure, which leads to a boost in blood nicotine concentration up to 2ng/mL, will result in the substantial occupancy of brain nAChRs. Conclusion: These findings suggest that nicotine from SHS exposure affects brain function through an interaction...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-08, Vol.52 (S1), p.S96-S96
Main Authors: Brody, A.L., Mandelkern, M.A., London, E.D., Khan, A., Kozman, D., Costello, M.R., Abrams, A.L., Olmstead, R.E., Mukhin, A.G.
Format: Article
Language:English
Subjects:
Cigarettes
Nicotine
Smoking
Tobacco smoke
Online Access:Get full text
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Summary:Based on this observation we hypothesized that SHS exposure, which leads to a boost in blood nicotine concentration up to 2ng/mL, will result in the substantial occupancy of brain nAChRs. Conclusion: These findings suggest that nicotine from SHS exposure affects brain function through an interaction with nAChRs, which may contribute to the initiation and maintenance of nicotine dependence in people exposed to SHS. [...]this study has implications for biological research into the link between SHS exposure and cigarette usage, and public policy regarding the need to limit SHS exposure.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.077