Sweat analysis using indirect ion-selective electrode on the routine chemistry analyser meets UK guidelines

Background According to consensus documents, sweat testing remains the standard for diagnosing cystic fibrosis. We studied a novel method of sweat analysis on two chemistry platforms: Dimension Vista (Siemens Healthcare Diagnostics) and Aeroset (Abbott). Methods Sweat collected from healthy individu...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2011-07, Vol.48 (4), p.374-376
Main Authors: Hulstein, Janine J J, van 't Sant, Peter
Format: Article
Language:English
Subjects:
Chlorides - analysis
Cystic Fibrosis - diagnosis
Humans
Ion-Selective Electrodes
Reference Standards
Sodium - analysis
Sweat - chemistry
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Summary:Background According to consensus documents, sweat testing remains the standard for diagnosing cystic fibrosis. We studied a novel method of sweat analysis on two chemistry platforms: Dimension Vista (Siemens Healthcare Diagnostics) and Aeroset (Abbott). Methods Sweat collected from healthy individuals and aqueous samples in the critical range for sweat analysis were measured using the Orion 290 plus (Thermo Electron Corporation), Chiron 925 chloride analyser (Sherwood Scientific Ltd), flame photometry, sweat-chek analyser and indirect ion-selective electrodes (ISE) of Vista and Aeroset. For measurement on ISE, an addition protocol was designed. Results Within-run and between-run variation coefficients of Aeroset and Vista remained
ISSN:0004-5632
1758-1001
DOI:10.1258/acb.2011.011001