Loading…
Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation
Background Power spectral analysis of heart rate variability is used to assess cardiac autonomic function. The relationship of low frequency (LF) power to cardiac sympathetic tone has been unclear. We reported previously that LF power may reflect baroreflex modulation. In this study we attempted to...
Saved in:
| Published in: | Clinical autonomic research 2011-06, Vol.21 (3), p.133-141 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53 |
| container_end_page | 141 |
| container_issue | 3 |
| container_start_page | 133 |
| container_title | Clinical autonomic research |
| container_volume | 21 |
| creator | Rahman, Faisal Pechnik, Sandra Gross, Daniel Sewell, LaToya Goldstein, David S. |
| description | Background
Power spectral analysis of heart rate variability is used to assess cardiac autonomic function. The relationship of low frequency (LF) power to cardiac sympathetic tone has been unclear. We reported previously that LF power may reflect baroreflex modulation. In this study we attempted to replicate our findings in additional subject cohorts, taking into account possible influences of respiration and using different methods to measure baroreflex-cardiovagal gain (BCG).
Objective
We assessed relationships of LF power, including respiration-adjusted LF power (LFa), with cardiac sympathetic innervation and baroreflex function in subjects with or without neuroimaging evidence of cardiac sympathetic denervation.
Methods
Values for LF power at baseline supine, seated, and during the Valsalva maneuver were compared between subject groups with low or normal myocardial concentrations of 6-[
18
F]fluorodopamine-derived radioactivity. BCG was calculated from the slope of cardiac interbeat interval vs. systolic pressure during Phase II of the Valsalva maneuver or after i.v. nitroglycerine injection (the Oxford technique).
Results
LF and LFa were unrelated to myocardial 6-[
18
F]fluorodopamine-derived radioactivity. During sitting rest and the Valsalva maneuver logs of LF and LFa correlated positively with the log of Phase II BCG (
r
= 0.61,
p
= 0.0005;
r
= 0.47,
p
= 0.009;
r
= 0.69,
p
|
| doi_str_mv | 10.1007/s10286-010-0098-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_876246251</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>876246251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EokvhB3BBFhcuDXj8FeeIKihIK3GBszVxHOoqGy-205J_j8MWkJAQJ2vkZ97RzEPIc2CvgbH2TQbGjW4YsIaxzjTrA7IDDV0DSrOHZMc61TWdUXBGnuR8wxgoI-AxOePA206C3JG4j3d0TP7b4me30mO884nGkV57TIUmLJ7eYgrYhymUlSY_Tt6VTHtM8WfxnY7L7EqI8wWdY6EO0xDQ0bwejliufQmOhnn26RY36Cl5NOKU_bP795x8ef_u8-WHZv_p6uPl233jpFSlkVowRBAG9OAVaC5AokNwpu11L6Ty4yB75sZBGYZCCzA4gDca2hY0KnFOXp1yjynW3XKxh5CdnyacfVyyNa3mUnMF_ye1VkLUg1by5V_kTVzSXNfYIK40N9tgOEEuxZzriewxhQOm1QKzmzV7smarNbtZs2vteXEfvPQHP_zu-KWpAvwE5Po1f_Xpz-R_p_4AQcOjuA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>866256285</pqid></control><display><type>article</type><title>Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation</title><source>Springer Nature</source><creator>Rahman, Faisal ; Pechnik, Sandra ; Gross, Daniel ; Sewell, LaToya ; Goldstein, David S.</creator><creatorcontrib>Rahman, Faisal ; Pechnik, Sandra ; Gross, Daniel ; Sewell, LaToya ; Goldstein, David S.</creatorcontrib><description>Background
Power spectral analysis of heart rate variability is used to assess cardiac autonomic function. The relationship of low frequency (LF) power to cardiac sympathetic tone has been unclear. We reported previously that LF power may reflect baroreflex modulation. In this study we attempted to replicate our findings in additional subject cohorts, taking into account possible influences of respiration and using different methods to measure baroreflex-cardiovagal gain (BCG).
Objective
We assessed relationships of LF power, including respiration-adjusted LF power (LFa), with cardiac sympathetic innervation and baroreflex function in subjects with or without neuroimaging evidence of cardiac sympathetic denervation.
Methods
Values for LF power at baseline supine, seated, and during the Valsalva maneuver were compared between subject groups with low or normal myocardial concentrations of 6-[
18
F]fluorodopamine-derived radioactivity. BCG was calculated from the slope of cardiac interbeat interval vs. systolic pressure during Phase II of the Valsalva maneuver or after i.v. nitroglycerine injection (the Oxford technique).
Results
LF and LFa were unrelated to myocardial 6-[
18
F]fluorodopamine-derived radioactivity. During sitting rest and the Valsalva maneuver logs of LF and LFa correlated positively with the log of Phase II BCG (
r
= 0.61,
p
= 0.0005;
r
= 0.47,
p
= 0.009;
r
= 0.69,
p
< 0.0001;
r
= 0.60,
p
= 0.0006). Groups with Low BCG (≤3 ms/mmHg) had low LF and LFa regardless of cardiac innervation. The log of LF power during supine rest correlated with the log of Oxford BCG (
r
= 0.74,
p
< 0.0001).
Conclusion
LF power, with or without respiratory adjustment, reflects baroreflex modulation and not cardiac sympathetic tone.</description><identifier>ISSN: 0959-9851</identifier><identifier>EISSN: 1619-1560</identifier><identifier>DOI: 10.1007/s10286-010-0098-y</identifier><identifier>PMID: 21279414</identifier><identifier>CODEN: CAURE9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Baroreflex - physiology ; Cardiology ; Case-Control Studies ; Diabetes ; Electrophysiologic Techniques, Cardiac - methods ; Endocrinology ; Gastroenterology ; Heart - innervation ; Heart - physiology ; Heart Rate - drug effects ; Heart Rate - physiology ; Humans ; Hypotension, Orthostatic - physiopathology ; Medicine ; Medicine & Public Health ; Multiple System Atrophy - physiopathology ; Neurology ; Nitroglycerin - pharmacology ; Ophthalmology ; Parkinson Disease - physiopathology ; Pure Autonomic Failure - physiopathology ; Research Article ; Sympathetic Nervous System - physiology ; Tomography, Emission-Computed ; Valsalva Maneuver - physiology ; Vasodilator Agents - pharmacology</subject><ispartof>Clinical autonomic research, 2011-06, Vol.21 (3), p.133-141</ispartof><rights>Springer-Verlag (outside the USA) 2011</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53</citedby><cites>FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21279414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahman, Faisal</creatorcontrib><creatorcontrib>Pechnik, Sandra</creatorcontrib><creatorcontrib>Gross, Daniel</creatorcontrib><creatorcontrib>Sewell, LaToya</creatorcontrib><creatorcontrib>Goldstein, David S.</creatorcontrib><title>Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation</title><title>Clinical autonomic research</title><addtitle>Clin Auton Res</addtitle><addtitle>Clin Auton Res</addtitle><description>Background
Power spectral analysis of heart rate variability is used to assess cardiac autonomic function. The relationship of low frequency (LF) power to cardiac sympathetic tone has been unclear. We reported previously that LF power may reflect baroreflex modulation. In this study we attempted to replicate our findings in additional subject cohorts, taking into account possible influences of respiration and using different methods to measure baroreflex-cardiovagal gain (BCG).
Objective
We assessed relationships of LF power, including respiration-adjusted LF power (LFa), with cardiac sympathetic innervation and baroreflex function in subjects with or without neuroimaging evidence of cardiac sympathetic denervation.
Methods
Values for LF power at baseline supine, seated, and during the Valsalva maneuver were compared between subject groups with low or normal myocardial concentrations of 6-[
18
F]fluorodopamine-derived radioactivity. BCG was calculated from the slope of cardiac interbeat interval vs. systolic pressure during Phase II of the Valsalva maneuver or after i.v. nitroglycerine injection (the Oxford technique).
Results
LF and LFa were unrelated to myocardial 6-[
18
F]fluorodopamine-derived radioactivity. During sitting rest and the Valsalva maneuver logs of LF and LFa correlated positively with the log of Phase II BCG (
r
= 0.61,
p
= 0.0005;
r
= 0.47,
p
= 0.009;
r
= 0.69,
p
< 0.0001;
r
= 0.60,
p
= 0.0006). Groups with Low BCG (≤3 ms/mmHg) had low LF and LFa regardless of cardiac innervation. The log of LF power during supine rest correlated with the log of Oxford BCG (
r
= 0.74,
p
< 0.0001).
Conclusion
LF power, with or without respiratory adjustment, reflects baroreflex modulation and not cardiac sympathetic tone.</description><subject>Baroreflex - physiology</subject><subject>Cardiology</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Electrophysiologic Techniques, Cardiac - methods</subject><subject>Endocrinology</subject><subject>Gastroenterology</subject><subject>Heart - innervation</subject><subject>Heart - physiology</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Hypotension, Orthostatic - physiopathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Neurology</subject><subject>Nitroglycerin - pharmacology</subject><subject>Ophthalmology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Pure Autonomic Failure - physiopathology</subject><subject>Research Article</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Tomography, Emission-Computed</subject><subject>Valsalva Maneuver - physiology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0959-9851</issn><issn>1619-1560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EokvhB3BBFhcuDXj8FeeIKihIK3GBszVxHOoqGy-205J_j8MWkJAQJ2vkZ97RzEPIc2CvgbH2TQbGjW4YsIaxzjTrA7IDDV0DSrOHZMc61TWdUXBGnuR8wxgoI-AxOePA206C3JG4j3d0TP7b4me30mO884nGkV57TIUmLJ7eYgrYhymUlSY_Tt6VTHtM8WfxnY7L7EqI8wWdY6EO0xDQ0bwejliufQmOhnn26RY36Cl5NOKU_bP795x8ef_u8-WHZv_p6uPl233jpFSlkVowRBAG9OAVaC5AokNwpu11L6Ty4yB75sZBGYZCCzA4gDca2hY0KnFOXp1yjynW3XKxh5CdnyacfVyyNa3mUnMF_ye1VkLUg1by5V_kTVzSXNfYIK40N9tgOEEuxZzriewxhQOm1QKzmzV7smarNbtZs2vteXEfvPQHP_zu-KWpAvwE5Po1f_Xpz-R_p_4AQcOjuA</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Rahman, Faisal</creator><creator>Pechnik, Sandra</creator><creator>Gross, Daniel</creator><creator>Sewell, LaToya</creator><creator>Goldstein, David S.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation</title><author>Rahman, Faisal ; Pechnik, Sandra ; Gross, Daniel ; Sewell, LaToya ; Goldstein, David S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Baroreflex - physiology</topic><topic>Cardiology</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Electrophysiologic Techniques, Cardiac - methods</topic><topic>Endocrinology</topic><topic>Gastroenterology</topic><topic>Heart - innervation</topic><topic>Heart - physiology</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Hypotension, Orthostatic - physiopathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>Neurology</topic><topic>Nitroglycerin - pharmacology</topic><topic>Ophthalmology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Pure Autonomic Failure - physiopathology</topic><topic>Research Article</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Tomography, Emission-Computed</topic><topic>Valsalva Maneuver - physiology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahman, Faisal</creatorcontrib><creatorcontrib>Pechnik, Sandra</creatorcontrib><creatorcontrib>Gross, Daniel</creatorcontrib><creatorcontrib>Sewell, LaToya</creatorcontrib><creatorcontrib>Goldstein, David S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical autonomic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Faisal</au><au>Pechnik, Sandra</au><au>Gross, Daniel</au><au>Sewell, LaToya</au><au>Goldstein, David S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation</atitle><jtitle>Clinical autonomic research</jtitle><stitle>Clin Auton Res</stitle><addtitle>Clin Auton Res</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>21</volume><issue>3</issue><spage>133</spage><epage>141</epage><pages>133-141</pages><issn>0959-9851</issn><eissn>1619-1560</eissn><coden>CAURE9</coden><abstract>Background
Power spectral analysis of heart rate variability is used to assess cardiac autonomic function. The relationship of low frequency (LF) power to cardiac sympathetic tone has been unclear. We reported previously that LF power may reflect baroreflex modulation. In this study we attempted to replicate our findings in additional subject cohorts, taking into account possible influences of respiration and using different methods to measure baroreflex-cardiovagal gain (BCG).
Objective
We assessed relationships of LF power, including respiration-adjusted LF power (LFa), with cardiac sympathetic innervation and baroreflex function in subjects with or without neuroimaging evidence of cardiac sympathetic denervation.
Methods
Values for LF power at baseline supine, seated, and during the Valsalva maneuver were compared between subject groups with low or normal myocardial concentrations of 6-[
18
F]fluorodopamine-derived radioactivity. BCG was calculated from the slope of cardiac interbeat interval vs. systolic pressure during Phase II of the Valsalva maneuver or after i.v. nitroglycerine injection (the Oxford technique).
Results
LF and LFa were unrelated to myocardial 6-[
18
F]fluorodopamine-derived radioactivity. During sitting rest and the Valsalva maneuver logs of LF and LFa correlated positively with the log of Phase II BCG (
r
= 0.61,
p
= 0.0005;
r
= 0.47,
p
= 0.009;
r
= 0.69,
p
< 0.0001;
r
= 0.60,
p
= 0.0006). Groups with Low BCG (≤3 ms/mmHg) had low LF and LFa regardless of cardiac innervation. The log of LF power during supine rest correlated with the log of Oxford BCG (
r
= 0.74,
p
< 0.0001).
Conclusion
LF power, with or without respiratory adjustment, reflects baroreflex modulation and not cardiac sympathetic tone.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21279414</pmid><doi>10.1007/s10286-010-0098-y</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-9851 |
| ispartof | Clinical autonomic research, 2011-06, Vol.21 (3), p.133-141 |
| issn | 0959-9851 1619-1560 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_876246251 |
| source | Springer Nature |
| subjects | Baroreflex - physiology Cardiology Case-Control Studies Diabetes Electrophysiologic Techniques, Cardiac - methods Endocrinology Gastroenterology Heart - innervation Heart - physiology Heart Rate - drug effects Heart Rate - physiology Humans Hypotension, Orthostatic - physiopathology Medicine Medicine & Public Health Multiple System Atrophy - physiopathology Neurology Nitroglycerin - pharmacology Ophthalmology Parkinson Disease - physiopathology Pure Autonomic Failure - physiopathology Research Article Sympathetic Nervous System - physiology Tomography, Emission-Computed Valsalva Maneuver - physiology Vasodilator Agents - pharmacology |
| title | Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T15%3A46%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20frequency%20power%20of%20heart%20rate%20variability%20reflects%20baroreflex%20function,%20not%20cardiac%20sympathetic%20innervation&rft.jtitle=Clinical%20autonomic%20research&rft.au=Rahman,%20Faisal&rft.date=2011-06-01&rft.volume=21&rft.issue=3&rft.spage=133&rft.epage=141&rft.pages=133-141&rft.issn=0959-9851&rft.eissn=1619-1560&rft.coden=CAURE9&rft_id=info:doi/10.1007/s10286-010-0098-y&rft_dat=%3Cproquest_cross%3E876246251%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c445t-4630aa13816de5162314aca1c87b6b345efd4b0cfd580a36318ad1e8617716a53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=866256285&rft_id=info:pmid/21279414&rfr_iscdi=true |