Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood–brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats

• Published in: Toxicology (Amsterdam) 2011-07, Vol.285 (1), p.31-38
• Main Authors: Qiu, Lian-Bo, Zhou, Yan, Wang, Qi, Yang, Long-long, Liu, Hai-Qiang, Xu, Sheng-Long, Qi, Yu-Hong, Ding, Gui-Rong, Guo, Guo-Zhen
• Format: Article
• Language: English
• Subjects: Animals; Attenuation; Biological and medical sciences; Blood-brain barrier; Blood-Brain Barrier - metabolism; Cerebral cortex; Degradation; Electromagnetic Fields; Electromagnetic pulse; Emergency; Gelatinase; gelatinase A; gelatinase B; Gelatinases - antagonists & inhibitors; Gelatinases - metabolism; gene expression; Heterocyclic Compounds, 1-Ring - pharmacology; Inhibitors; Male; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinases; Matrix Metalloproteinases - metabolism; Medical sciences; Membrane Proteins - metabolism; messenger RNA; Permeability; Phosphoproteins - metabolism; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger - metabolism; Sulfones - pharmacology; tight junctions; Time Factors; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Toxicology; ZO-1; Zonula Occludens-1 Protein
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2011.03.019

Highlights ► Blood-brain-barrier (BBB) disruption was induced by Electromagnetic pulse (EMP). ► BBB tight junction protein ZO-1 level decreased after EMP exposure. ► Gelatinases activity increased in BBB after EMP exposure. ► Gelatinases inhibitor attenuated EMP-induced BBB disruption and ZO-1 degradation. ► EMP-induced BBB disruption contributed to the degradation of ZO-1 by gelatinases.