Increased IL-33 expression by epithelial cells in bronchial asthma

In asthma, several reports documented intense epithelial cell turnover caused by cell damage/death and aberrant repair leading to thickening of epithelium.8 Recent studies on IL-33-expressing endothelial cells reported significant release of IL-33 in supernatants of damaged and/or necrotic endotheli...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-03, Vol.125 (3), p.752-754
Main Authors: Préfontaine, David, MSc, Nadigel, Jessica, BSc, Chouiali, Fazila, MSc, Audusseau, Séverine, MSc, Semlali, Abdelhabib, PhD, Chakir, Jamila, PhD, Martin, James G., MD, DSc, Hamid, Qutayba, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Asthma
Asthma - immunology
Asthma - metabolism
Biological and medical sciences
Biomarkers - analysis
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - immunology
Chronic obstructive pulmonary disease, asthma
Cytokines
Enzyme-Linked Immunosorbent Assay
Epithelial Cells - immunology
Epithelial Cells - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Expression
Humans
Immunohistochemistry
Immunopathology
Interleukin-33
Interleukins - biosynthesis
Interleukins - immunology
Medical sciences
Pneumology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Smooth muscle
Studies
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Summary:In asthma, several reports documented intense epithelial cell turnover caused by cell damage/death and aberrant repair leading to thickening of epithelium.8 Recent studies on IL-33-expressing endothelial cells reported significant release of IL-33 in supernatants of damaged and/or necrotic endothelial cells compared with supernatants from live cells.9 It is therefore tempting to speculate that increased epithelial damage caused by chronic inflammation of the asthmatic bronchi contributes to the release of IL-33.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.12.935