Obesity and ischemic heart disease. Is there a link between wellness' diseases?

Obesity, the most common nutritional disorder in Western countries, is usually associated to cardiovascular diseases. However, the precise molecular pathways underlying this close association remain poorly understood. Nowadays, the adipose tissue is considered as an endocrine organ able to produce s...

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Bibliographic Details
Published in:Monaldi archives for chest disease 2011-03, Vol.76 (1), p.13-21
Main Authors: Maresca, Fabio, D'Ascoli, Greta Luana, Ziviello, Francesca, Petrillo, Gianluca, Di Palma, Vito, Russo, Angelo, Grieco, Alessandra, Cirillo, Plinio
Format: Article
Language:Italian
Subjects:
Adipokines - physiology
Adipose Tissue - metabolism
Cardiovascular Diseases - etiology
Endothelium, Vascular - physiology
Humans
Inflammation - complications
Interleukin-6 - blood
Myocardial Ischemia - etiology
Obesity - complications
Obesity - physiopathology
Tumor Necrosis Factor-alpha - blood
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Summary:Obesity, the most common nutritional disorder in Western countries, is usually associated to cardiovascular diseases. However, the precise molecular pathways underlying this close association remain poorly understood. Nowadays, the adipose tissue is considered as an endocrine organ able to produce substances called adipo(cyto)kines that have different effects on lipid metabolism, closely involved in metabolic syndrome, and cardiovascular risk. The increased cardiovascular risk can be related also to peculiar dysfunction in the endocrine activity of adipose tissue observed in obesity responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. The present review aims at providing an up-dated overview on the adipocyte-derived molecules potentially involved in cardiovascular pathophysiology.
ISSN:1122-0643