Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1

• Published in: British journal of surgery 2011-07, Vol.98 (7), p.935-942
• Main Authors: Brown, L. C., Thompson, S. G., Greenhalgh, R. M., Powell, J. T.
• Format: Article
• Language: English
• Subjects: Aged; Aortic Aneurysm, Abdominal - mortality; Aortic Aneurysm, Abdominal - surgery; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the aorta; Endovascular Procedures - mortality; Epidemiology; Female; General aspects; Humans; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Myocardial Infarction - etiology; Myocardial Infarction - mortality; Postoperative Complications - etiology; Postoperative Complications - mortality; Public health. Hygiene; Public health. Hygiene-occupational medicine; Stroke - etiology; Stroke - mortality
• ISSN: 0007-1323; 1365-2168
• DOI: 10.1002/bjs.7485

Background: The aim was to compare rates of myocardial infarction, stroke and cardiovascular death in patients with a large abdominal aortic aneurysm who had endovascular (EVAR) or open repair to determine whether cardiovascular mortality explains the convergence in survival curves after these procedures. Methods: Between 1999 and 2004, 1252 patients were randomized to EVAR or open repair in the UK EVAR trial 1. All patients were followed for death, myocardial infarction or stroke until September 2009. Cox regression was used to compare cardiovascular events and deaths between the randomized groups during different time intervals. Results: Over 5 years of follow‐up, a total of 187 first non‐fatal or fatal cardiovascular events (98 myocardial infarctions and 89 strokes) and 256 cardiovascular deaths occurred. Although the endovascular group had a lower cardiovascular event rate than the open repair group (2·6 versus 3·2 per 100 person‐years respectively) this was not statistically significant (adjusted hazard ratio (HR) 0·83, 95 per cent confidence interval 0·62 to 1·10; P = 0·199). Overall, there was little difference in cardiovascular mortality between the randomized groups (adjusted HR 1·06, 0·83 to 1·36; P = 0·638), but a non‐significant excess of cardiovascular deaths was apparent in the endovascular group during the 6–24‐month interval (adjusted HR 1·44, 0·79 to 2·62; P = 0·237). Conclusion: Patients who had EVAR appeared to have a lower subsequent cardiovascular event rate during all time intervals. Cardiovascular mortality was similar between the two groups overall, but more cardiovascular deaths in the EVAR group appeared to contribute to the convergence in all‐cause mortality during the first 2 years. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Not the full answer