Efficacy of emodepside plus toltrazuril (Procox(®) oral suspension for dogs) against Toxocara canis, Uncinaria stenocephala and Ancylostoma caninum in dogs

• Published in: Parasitology research (1987) 2011-08, Vol.109 Suppl 1, p.S1-S8
• Main Authors: Schimmel, Annette, Schroeder, Iris, Altreuther, Gertraut, Settje, Terry, Charles, Samuel, Wolken, Sonja, Kok, Dawid J, Ketzis, Jennifer, Young, David, Hutchens, Douglas, Krieger, Klemens J
• Format: Article
• Language: English
• Subjects: Administration, Oral; Ancylostoma - drug effects; Ancylostoma - pathogenicity; Ancylostomatoidea - drug effects; Ancylostomatoidea - pathogenicity; Animals; Anthelmintics - administration & dosage; Anthelmintics - therapeutic use; Depsipeptides - administration & dosage; Depsipeptides - therapeutic use; Dog Diseases - drug therapy; Dog Diseases - parasitology; Dogs; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Hookworm Infections - drug therapy; Hookworm Infections - parasitology; Hookworm Infections - veterinary; Larva - drug effects; Larva - parasitology; Male; Parasite Egg Count - veterinary; Toxocara canis - drug effects; Toxocara canis - pathogenicity; Toxocariasis - drug therapy; Toxocariasis - parasitology; Triazines - administration & dosage; Triazines - therapeutic use
• ISSN: 1432-1955
• DOI: 10.1007/s00436-011-2397-1

The efficacy of emodepside plus toltrazuril (Procox® oral suspension for dogs) against different species of gastrointestinal nematodes (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala) was evaluated in nine randomised,blinded and placebo-controlled laboratory studies in naturally or experimentally infected dogs. The product was used at the proposed minimum dose of 0.45 mg emodepside and 9 mg toltrazuril per kg body weight. Efficacy was calculated based on worm counts after necropsy. Worm burdens in the control dogs ranged between 0 and 409 worms of the respective stage for T. canis and between 4 and 655 worms for hookworms. The studies demonstrated 100 % efficacy of emodepside/toltrazuril suspension against mature adult, ≥ 94.7 %efficacy against immature adult and 99.3 % efficacy against the L4 larval stage of T. canis. The efficacy against mature adult A. caninum was ≥ 99.5 % and the efficacy against mature adult U. stenocephala was 100 %. All differences between treatment and control groups were statistically significant and no gender effect was found. It can be concluded that the emodepside/toltrazuril suspension represents a safe and highly effective product in dogs with nematode (T. canis, hookworms) infection.