Morphological variability of NADPH diaphorase neurons across areas V1, V2, and V3 of the common agouti

Abstract Previous studies have shown a noticeable phenotypic diversity for pyramidal cells among cortical areas in the cerebral cortex. Both the extent and systematic nature of this variation suggests a correlation with particular aspects of cortical processing. Nevertheless, regional variations in...

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Bibliographic Details
Published in:Brain research 2010-03, Vol.1318, p.52-63
Main Authors: Freire, Marco Aurélio M, Rocha, Emiliana G, Oliveira, Jorge Luiz F, Guimarães, Joanilson S, Silveira, Luiz Carlos L, Elston, Guy N, Pereira, Antonio, Picanço-Diniz, Cristovam W
Format: Article
Language:English
Subjects:
Animals
Area 17
Area 18
Biological and medical sciences
Cell Size
Cluster Analysis
Dendrites - enzymology
Dendrites - metabolism
Extrastriate
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Imaging, Three-Dimensional
Interneuron
Male
NADPH Dehydrogenase - metabolism
Neurology
Neurons - cytology
Neurons - enzymology
Neurons - metabolism
Photomicrography
Rodent
Rodentia
Striate
Vertebrates: nervous system and sense organs
Visual Cortex - cytology
Visual Cortex - enzymology
Visual Cortex - metabolism
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Summary:Abstract Previous studies have shown a noticeable phenotypic diversity for pyramidal cells among cortical areas in the cerebral cortex. Both the extent and systematic nature of this variation suggests a correlation with particular aspects of cortical processing. Nevertheless, regional variations in the morphology of inhibitory cells have not been evaluated with the same detail. In the present study we performed a 3D morphometric analysis of 120 NADPH diaphorase (NADPH-d) type I neurons in the visual cortex of a South American Hystricomorph rodent, the diurnal agouti ( Dasyprocta sp.). We found significant differences in morphology of NADPH-d type I neurons among visual cortical areas: cells became progressively larger and more branched from V1 to V2 and V3. Presumably, the specialized morphology of these cells is correlated with different sampling geometry and function. The data suggest that area-specific specializations of cortical inhibitory circuitry are also present in rodents.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2009.12.045