Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection

Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucl...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2010-05, Vol.25 (9), p.2182-2185
Main Authors: Ryu, Seong-Wan, Kim, Chang-Hoon, Han, Jin-Woo, Kim, Chung-Jin, Jung, Cheulhee, Park, Hyun Gyu, Choi, Yang-Kyu
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Biosensing Techniques - instrumentation
Biosensors
Biotechnology
Breast Neoplasms - genetics
DNA
DNA - analysis
DNA - genetics
DNA Probes - genetics
DNA, Neoplasm - analysis
DNA, Neoplasm - genetics
Electrochemical Techniques
Female
Fundamental and applied biological sciences. Psychology
General aspects
Gold
Gold nanoparticle
Humans
Hybridization
Immobilization techniques
Metal Nanoparticles - ultrastructure
Methods. Procedures. Technologies
Microscopy, Electron, Scanning
Nanowires - ultrastructure
Oligonucleotide immobilization
Silicon
Silicon nanowire
Various methods and equipments
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Summary:Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides. The complementary target oligonucleotide, breast cancer DNA with 1 pM, was sensed. In addition, its sensing mechanism and limit of detection (LOD) enhancement was investigated through simulation. The results support that the LOD can be improved by reducing the SiNW doping concentration. This emerging architecture combined nanostructure of spherical GN and SiNW has high potential as a label-free biosensor due to its facile fabrication process, high thermal stability, immobilization efficiency with a thiol-group in a self-assembled monolayer (SAM), and improved sensitivity.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2010.02.010