Use of magnetic resonance imaging (MRI) and micro-computed tomography (micro-CT) in the morphological examination of rat and rabbit fetuses from embryo-fetal development studies

Images of the fetal skeleton and soft tissues of the head can be acquired using micro-CT and MRI respectively. Preliminary work has shown that the image acquisition times of commercially available micro-CT and MRI instruments are now sufficiently short, whilst still providing adequate image resoluti...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-09, Vol.30 (2), p.292-300
Main Authors: French, Julian, Gingles, Neill, Stewart, Jane, Woodhouse, Neil
Format: Article
Language:English
Subjects:
Alizarin red S
Animals
Biological and medical sciences
Bouin's fluid
Computed tomography
Embryo, Mammalian - diagnostic imaging
Embryo, Mammalian - embryology
Embryo, Mammalian - physiology
Embryology: invertebrates and vertebrates. Teratology
Embryonic Development - physiology
Fetal
Fetal Development - physiology
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Imaging - methods
Medical sciences
Micro-CT
MRI
Rabbit
Rabbits
Rat
Rats
Reproductive toxicology
Teratology. Teratogens
Toxicity Tests - methods
Toxicology
X-Ray Microtomography - methods
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Summary:Images of the fetal skeleton and soft tissues of the head can be acquired using micro-CT and MRI respectively. Preliminary work has shown that the image acquisition times of commercially available micro-CT and MRI instruments are now sufficiently short, whilst still providing adequate image resolution, to allow high quality imaging of fetuses from embryo-fetal development (EFD) studies . Bespoke fetus holders, which allow the imaging of multiple specimens in a single imaging “run”, have been used to increase throughput. Protocols have been devised that incorporate these technologies into routine rat and rabbit fetal examination regimes. It is intended to undertake evaluations of these protocols, using number of fetuses that replicate those that would be expected from normal EFD studies. Incorporation of these technologies is anticipated to allow all soft tissue and skeletal examination data to be collected on the same day, markedly reducing the time taken to provide data for evaluation.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2010.04.016