Dorsolateral prefrontal cortex stimulation modulates electrocortical measures of visual attention: evidence from direct bilateral epidural cortical stimulation in treatment-resistant mood disorder

Abstract Electrocortical activity is increasingly being used to study emotion regulation and the impact of cognitive control on neural response to visual stimuli. In the current study, we used direct epidural cortical stimulation (EpCS) to examine regional specificity of PFC stimulation on the parie...

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Bibliographic Details
Published in:Neuroscience 2010-09, Vol.170 (1), p.281-288
Main Authors: Hajcak, G, Anderson, B.S, Arana, A, Borckardt, J, Takacs, I, George, M.S, Nahas, Z
Format: Article
Language:English
Subjects:
Adult
Arousal
attention
Attention - physiology
Biological and medical sciences
brain stimulation
Deep Brain Stimulation - methods
Epidural Space - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
IAPS
late positive potential
Male
Middle Aged
Mood Disorders - physiopathology
Mood Disorders - psychology
Mood Disorders - therapy
Neurology
Photic Stimulation - methods
Prefrontal Cortex - physiology
Treatment Outcome
Vertebrates: nervous system and sense organs
Visual Perception - physiology
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Summary:Abstract Electrocortical activity is increasingly being used to study emotion regulation and the impact of cognitive control on neural response to visual stimuli. In the current study, we used direct epidural cortical stimulation (EpCS) to examine regional specificity of PFC stimulation on the parietally-maximal late positive potential (LPP), an event-related potential (ERP) biomarker of visual attention to salient stimuli. Five patients with treatment-resistant mood disorders were stereotactically implanted with stimulating paddles over frontopolar (FP) and dorsolateral (DL) prefrontal cortex bilaterally. On their first day of activation, patients underwent sham-controlled EpCS coupled with 64-channel electroencephalograph (EEG) recordings and passive viewing of aversive and neutral images. In addition to sham, patients had either FP or DL prefrontal cortex stimulated at 2 or 4 V while they viewed neutral and aversive pictures. As expected during the sham condition, LPP was larger for aversive compared to neutral stimuli ( F (1,4)=232.07, P
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2010.04.069