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A one-generation reproductive toxicity study of ethyl tertiary butyl ether in rats
A one-generation reproductive toxicity study was conducted to evaluate the effects of ethyl tertiary butyl ether (ETBE), a bio-fuel, on reproduction of parental rats, as well as development and growth of their offspring at dose levels of 0, 100, 300 and 1000 mg/kg-d by gavage. No treatment-related c...
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| Published in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-11, Vol.30 (3), p.414-421 |
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| Language: | English |
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| container_end_page | 421 |
| container_issue | 3 |
| container_start_page | 414 |
| container_title | Reproductive toxicology (Elmsford, N.Y.) |
| container_volume | 30 |
| creator | Fujii, Sakiko Yabe, Kaoru Furukawa, Masatoshi Matsuura, Masao Aoyama, Hiroaki |
| description | A one-generation reproductive toxicity study was conducted to evaluate the effects of ethyl tertiary butyl ether (ETBE), a bio-fuel, on reproduction of parental rats, as well as development and growth of their offspring at dose levels of 0, 100, 300 and 1000
mg/kg-d by gavage. No treatment-related changes were observed in either F0 parents or their F1 offspring in the 100 and 300
mg/kg groups in any parameters examined. Some parental animals in the 1000
mg/kg group exhibited transient salivation, possibly a reflex to a bitter taste of ETBE, immediately after dosing, although their body weights, food consumption, reproductive parameters, and gross pathological findings were not affected. Their absolute and relative liver weights increased significantly in the 1000
mg/kg group, suggesting enhanced activities of metabolic enzymes. Pup viability was slightly reduced during the early lactation period in the 1000
mg/kg group. These results lead to the conclusion that the no-observed-adverse-effect-level (NOAEL) of ETBE on both parental rats and their offspring is 300
mg/kg-d under the current study condition. |
| doi_str_mv | 10.1016/j.reprotox.2010.04.013 |
| format | article |
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mg/kg-d by gavage. No treatment-related changes were observed in either F0 parents or their F1 offspring in the 100 and 300
mg/kg groups in any parameters examined. Some parental animals in the 1000
mg/kg group exhibited transient salivation, possibly a reflex to a bitter taste of ETBE, immediately after dosing, although their body weights, food consumption, reproductive parameters, and gross pathological findings were not affected. Their absolute and relative liver weights increased significantly in the 1000
mg/kg group, suggesting enhanced activities of metabolic enzymes. Pup viability was slightly reduced during the early lactation period in the 1000
mg/kg group. These results lead to the conclusion that the no-observed-adverse-effect-level (NOAEL) of ETBE on both parental rats and their offspring is 300
mg/kg-d under the current study condition.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2010.04.013</identifier><identifier>PMID: 20438832</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biofuels ; Biological and medical sciences ; Developmental landmarks ; Dose-Response Relationship, Drug ; Embryology: invertebrates and vertebrates. Teratology ; Environmental Pollutants - toxicity ; Ethyl Ethers - toxicity ; Ethyl tertiary butyl ether (ETBE) ; Female ; Fertility ; Fundamental and applied biological sciences. Psychology ; Male ; Medical sciences ; No-Observed-Adverse-Effect Level ; One-generation ; Pregnancy ; Rat ; Rats ; Rats, Sprague-Dawley ; Reproduction - drug effects ; Reproductive toxicity ; Teratology. Teratogens ; Toxicity Tests, Chronic - methods ; Toxicology</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2010-11, Vol.30 (3), p.414-421</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-c3f19b3d5d25e7edd5a943f09f9ea1394ad30e681d873a209de9bc47286829103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23292830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20438832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujii, Sakiko</creatorcontrib><creatorcontrib>Yabe, Kaoru</creatorcontrib><creatorcontrib>Furukawa, Masatoshi</creatorcontrib><creatorcontrib>Matsuura, Masao</creatorcontrib><creatorcontrib>Aoyama, Hiroaki</creatorcontrib><title>A one-generation reproductive toxicity study of ethyl tertiary butyl ether in rats</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>A one-generation reproductive toxicity study was conducted to evaluate the effects of ethyl tertiary butyl ether (ETBE), a bio-fuel, on reproduction of parental rats, as well as development and growth of their offspring at dose levels of 0, 100, 300 and 1000
mg/kg-d by gavage. No treatment-related changes were observed in either F0 parents or their F1 offspring in the 100 and 300
mg/kg groups in any parameters examined. Some parental animals in the 1000
mg/kg group exhibited transient salivation, possibly a reflex to a bitter taste of ETBE, immediately after dosing, although their body weights, food consumption, reproductive parameters, and gross pathological findings were not affected. Their absolute and relative liver weights increased significantly in the 1000
mg/kg group, suggesting enhanced activities of metabolic enzymes. Pup viability was slightly reduced during the early lactation period in the 1000
mg/kg group. These results lead to the conclusion that the no-observed-adverse-effect-level (NOAEL) of ETBE on both parental rats and their offspring is 300
mg/kg-d under the current study condition.</description><subject>Animals</subject><subject>Biofuels</subject><subject>Biological and medical sciences</subject><subject>Developmental landmarks</subject><subject>Dose-Response Relationship, Drug</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Environmental Pollutants - toxicity</subject><subject>Ethyl Ethers - toxicity</subject><subject>Ethyl tertiary butyl ether (ETBE)</subject><subject>Female</subject><subject>Fertility</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>No-Observed-Adverse-Effect Level</subject><subject>One-generation</subject><subject>Pregnancy</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproduction - drug effects</subject><subject>Reproductive toxicity</subject><subject>Teratology. Teratogens</subject><subject>Toxicity Tests, Chronic - methods</subject><subject>Toxicology</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkM1OJCEURonRaI_6CobNxFW1F6gqYKcx_kxiYmJ0TWi45dCprnKAMtNvL223znJWhJvzXT4OIWcM5gxYe7GcR3yLYx7_zjmUIdRzYGKPzJiSomIS1D6ZgdJQtVyoI_IjpSUA1FLLQ3LEoRZKCT4jT1d0HLB6xQGjzWEc6OdeP7kc3pGW_cGFvKYpT35Nx45i_r3uacaYg41ruphyuZYhRhpK2OZ0Qg462yc83Z3H5OX25vn6vnp4vPt1ffVQuVo3uXKiY3ohfON5gxK9b6yuRQe602iZ0LX1ArBVzJcfWQ7ao164WnLVKq4ZiGNyvt1b-v6ZMGWzCslh39sBxykZJWWj20bIQrZb0sUxpYideYthVeobBmaj0yzNl06z0WmgNkVnCZ7tnpgWK_TfsS9_Bfi5A2xytu-iHVxI_zjBNVdi0_Vyy2ER8h4wmuQCDg59iOiy8WP4X5cPuBGYCg</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Fujii, Sakiko</creator><creator>Yabe, Kaoru</creator><creator>Furukawa, Masatoshi</creator><creator>Matsuura, Masao</creator><creator>Aoyama, Hiroaki</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20101101</creationdate><title>A one-generation reproductive toxicity study of ethyl tertiary butyl ether in rats</title><author>Fujii, Sakiko ; Yabe, Kaoru ; Furukawa, Masatoshi ; Matsuura, Masao ; Aoyama, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-c3f19b3d5d25e7edd5a943f09f9ea1394ad30e681d873a209de9bc47286829103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biofuels</topic><topic>Biological and medical sciences</topic><topic>Developmental landmarks</topic><topic>Dose-Response Relationship, Drug</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Environmental Pollutants - toxicity</topic><topic>Ethyl Ethers - toxicity</topic><topic>Ethyl tertiary butyl ether (ETBE)</topic><topic>Female</topic><topic>Fertility</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>No-Observed-Adverse-Effect Level</topic><topic>One-generation</topic><topic>Pregnancy</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproduction - drug effects</topic><topic>Reproductive toxicity</topic><topic>Teratology. Teratogens</topic><topic>Toxicity Tests, Chronic - methods</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujii, Sakiko</creatorcontrib><creatorcontrib>Yabe, Kaoru</creatorcontrib><creatorcontrib>Furukawa, Masatoshi</creatorcontrib><creatorcontrib>Matsuura, Masao</creatorcontrib><creatorcontrib>Aoyama, Hiroaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, Sakiko</au><au>Yabe, Kaoru</au><au>Furukawa, Masatoshi</au><au>Matsuura, Masao</au><au>Aoyama, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A one-generation reproductive toxicity study of ethyl tertiary butyl ether in rats</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>30</volume><issue>3</issue><spage>414</spage><epage>421</epage><pages>414-421</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>A one-generation reproductive toxicity study was conducted to evaluate the effects of ethyl tertiary butyl ether (ETBE), a bio-fuel, on reproduction of parental rats, as well as development and growth of their offspring at dose levels of 0, 100, 300 and 1000
mg/kg-d by gavage. No treatment-related changes were observed in either F0 parents or their F1 offspring in the 100 and 300
mg/kg groups in any parameters examined. Some parental animals in the 1000
mg/kg group exhibited transient salivation, possibly a reflex to a bitter taste of ETBE, immediately after dosing, although their body weights, food consumption, reproductive parameters, and gross pathological findings were not affected. Their absolute and relative liver weights increased significantly in the 1000
mg/kg group, suggesting enhanced activities of metabolic enzymes. Pup viability was slightly reduced during the early lactation period in the 1000
mg/kg group. These results lead to the conclusion that the no-observed-adverse-effect-level (NOAEL) of ETBE on both parental rats and their offspring is 300
mg/kg-d under the current study condition.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20438832</pmid><doi>10.1016/j.reprotox.2010.04.013</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2010-11, Vol.30 (3), p.414-421 |
| issn | 0890-6238 1873-1708 |
| language | eng |
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| source | Elsevier |
| subjects | Animals Biofuels Biological and medical sciences Developmental landmarks Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Environmental Pollutants - toxicity Ethyl Ethers - toxicity Ethyl tertiary butyl ether (ETBE) Female Fertility Fundamental and applied biological sciences. Psychology Male Medical sciences No-Observed-Adverse-Effect Level One-generation Pregnancy Rat Rats Rats, Sprague-Dawley Reproduction - drug effects Reproductive toxicity Teratology. Teratogens Toxicity Tests, Chronic - methods Toxicology |
| title | A one-generation reproductive toxicity study of ethyl tertiary butyl ether in rats |
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