Psychiatric Manifestations of Paraneoplastic Disorders

Paraneoplastic disorders of the CNS result from immune responses to neuronal proteins expressed by tumors found elsewhere in the body. Limbic encephalitis, one of the most common manifestations of paraneoplastic disorders, is characterized by rapid onset of psychiatric and neurological symptoms that...

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Bibliographic Details
Published in:The American journal of psychiatry 2010-09, Vol.167 (9), p.1039-1050
Main Authors: Kayser, Matthew S., Kohler, Christian G., Dalmau, Josep
Format: Article
Language:English
Subjects:
Autoantibodies - immunology
Autoimmune Diseases - diagnosis
Autoimmune Diseases - immunology
Behavior
Biological and medical sciences
Cancer
Cognition & reasoning
Diagnosis, Differential
ELAV Proteins - immunology
Humans
Infections
Limbic Encephalitis - diagnosis
Limbic Encephalitis - immunology
Medical research
Medical sciences
Mental Disorders - diagnosis
Mental Disorders - immunology
Nerve Tissue Proteins - immunology
Neurosciences
Paraneoplastic Syndromes, Nervous System - diagnosis
Paraneoplastic Syndromes, Nervous System - immunology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Paraneoplastic disorders of the CNS result from immune responses to neuronal proteins expressed by tumors found elsewhere in the body. Limbic encephalitis, one of the most common manifestations of paraneoplastic disorders, is characterized by rapid onset of psychiatric and neurological symptoms that often culminate in severe neurological deterioration. Recent work has described paraneoplastic syndromes with prominent, and sometimes isolated, psychiatric symptoms for which patients are fi rst seen by a psychiatrist. Here the authors review the existing literature on psychiatric and behavioral manifestations of paraneoplastic disorders, the cellular mechanisms underlying these syndromes, and current treatment and outcomes. They also discuss the broad behavioral fi ndings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders.
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2010.09101547