Trace Elements Status in Selenium-Deficient Rats—Interaction with Cadmium

Although the metabolic and toxicological interactions between essential element selenium (Se) and toxic element cadmium (Cd) have been reported for a long time, the experimental studies explored mostly acute, high-dose interactions. Limited data are available regarding the effects of Se-deficiency o...

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Bibliographic Details
Published in:Biological trace element research 2010-09, Vol.136 (3), p.287-293
Main Authors: Kotyzová, Dana, Černá, Pavla, Lešetický, Ladislav, Eybl, Vladislav
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cadmium
Cadmium - administration & dosage
Cadmium - metabolism
Cadmium - pharmacokinetics
Cadmium chloride
Cadmium Chloride - metabolism
Cadmium Chloride - pharmacokinetics
Copper
Data processing
Diet
Dietary minerals
Dietary supplements
Diets
Drinking water
Female
Iron
Life Sciences
Liver
Male
Nutrition
Oncology
Rats
Rats, Wistar
Rodents
Selenium
Selenium - administration & dosage
Selenium - deficiency
Selenium - metabolism
Spectrophotometry, Atomic
Time Factors
Toxicology
Trace elements
Trace Elements - metabolism
Trace Elements - pharmacokinetics
Weaning
Zinc
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Summary:Although the metabolic and toxicological interactions between essential element selenium (Se) and toxic element cadmium (Cd) have been reported for a long time, the experimental studies explored mostly acute, high-dose interactions. Limited data are available regarding the effects of Se-deficiency on toxicokinetics of cadmium, as well as on the levels of key trace elements—copper, zinc, and iron. In the present study, male and female Wistar weanling rats (n = 40/41) were fed either Se-deficient or Se-adequate diet (
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-009-8541-4