Patent Foramen Ovale in Children with Migraine Headaches

Objective To determine the prevalence of patent foramen ovale (PFO) in children with migraine. Study design Children aged 6.0 to 18.0 years with migraine headache were evaluated for PFO and right-to-left shunting with color-flow Doppler scanning, saline solution contrast transthoracic echocardiograp...

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Bibliographic Details
Published in:The Journal of pediatrics 2011-08, Vol.159 (2), p.243-247.e1
Main Authors: McCandless, Rachel T., MD, Arrington, Cammon B., MD, Nielsen, Douglas C, Bale, James F., MD, Minich, L. LuAnn, MD
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Cardiology. Vascular system
Child
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Echocardiography, Doppler, Color
Female
Follow-Up Studies
Foramen Ovale, Patent - complications
Foramen Ovale, Patent - diagnostic imaging
Foramen Ovale, Patent - epidemiology
General aspects
Heart
Humans
Male
Medical sciences
Migraine Disorders - complications
Migraine Disorders - diagnostic imaging
Migraine Disorders - epidemiology
Neurology
Pediatrics
Prevalence
Prognosis
Retrospective Studies
Risk Factors
Ultrasonography, Doppler, Transcranial
United States - epidemiology
Vascular diseases and vascular malformations of the nervous system
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Summary:Objective To determine the prevalence of patent foramen ovale (PFO) in children with migraine. Study design Children aged 6.0 to 18.0 years with migraine headache were evaluated for PFO and right-to-left shunting with color-flow Doppler scanning, saline solution contrast transthoracic echocardiography, and contrast transcranial Doppler scanning. Results The population consisted of 109 children with migraine; 38 (35%) with aura and 71 (65%) without aura. The overall PFO prevalence was 35%, similar to the general population (35% vs 25%; P = .13). However, compared with the general population (25%), the PFO prevalence was significantly greater in subjects with aura (50%, P = .0004) but similar in those without aura (27%, P = .73). Atrial shunt size was not associated with the presence or absence of aura. Conclusion Children with migraine with aura have a significantly higher prevalence of PFO compared with those without aura or the general population. These data suggest that PFO may contribute to the pathogenesis of migraine with aura in children and have implications for clinical decision making.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2011.01.062